Methyl 6-chloro-5-(trifluoroMethyl)nicotinate

Base Information

• Chemical Name: Methyl 6-chloro-5-(trifluoroMethyl)nicotinate
• CAS No.: 1360952-35-7
• Molecular Formula: C8H5ClF3NO2
• Molecular Weight: 239.581
• Mol file: 1360952-35-7.mol

Synonyms:Methyl 6-chloro-5-(trifluoroMethyl)nicotinate;6-Chloro-5-(trifluoromethyl)-3-pyridinecarboxylic acid methyl ester;ethyl 6-chloro-5-(trifluoromethyl)nicotinate

Chemical Property of Methyl 6-chloro-5-(trifluoroMethyl)nicotinate

Chemical Property:

• Boiling Point: 257.1±40.0 °C(Predicted)
• PKA: -3.89±0.10(Predicted)
• PSA: 39.19000
• Density: 1.443±0.06 g/cm3(Predicted)
• LogP: 2.54040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl6-Chloro-5-(Trifluoromethyl)nicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-chloro-5-(trifluoroMethyl)nicotinate

There total 14 articles about Methyl 6-chloro-5-(trifluoroMethyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-iodo-3-(trifluoromethyl)pyridine (887707-25-7) + methanol (67-56-1) + carbon monoxide (201230-82-2) → methyl 6-chloro-5-(trifluoromethyl)nicotinate (1360952-35-7)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate; at 80 ℃; for 10h;

Reference yield:

metyhyl chlorodifluoroacetate (1514-87-0) + 6-chloro-5-iodonicotinic acid methyl ester (365413-29-2) → methyl 6-chloro-5-(trifluoromethyl)nicotinate (1360952-35-7)

Guidance literature:

With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 3h; Reagent/catalyst; Solvent; Temperature; Concentration; Inert atmosphere; Large scale;

DOI:10.1021/op400061w

Reference yield:

6-chloro-5-iodonicotinic acid methyl ester (365413-29-2) → methyl 6-chloro-5-(trifluoromethyl)nicotinate (1360952-35-7) + 5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester (78686-77-8)

Guidance literature:

With potassium fluoride; metyhyl chlorodifluoroacetate; copper(I) bromide; In N,N-dimethyl acetamide; at 120 ℃;

DOI:10.1021/op400061w

upstream raw materials:

metyhyl chlorodifluoroacetate

6-chloro-5-iodonicotinic acid methyl ester

6-hydroxy-3-pyridinecarboxylic acid

methyl 6-hydroxynicotinate

Refernces

• 1、 -. "AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND PREPARATION METHOD AND APPLICATION OF AROMATIC RING DERIVATIVE". . . Retrieved 2021/10/15.