7-bromo-4,5-dihydro-5-phenyl-4-propionyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:7-bromo-4,5-dihydro-5-phenyl-4-propionyl-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:313683-81-7
Molecular Formula:C18H17BrN2O2
Molecular Weight:373.24
Hs Code.:
Mol file:313683-81-7.mol

Synonyms:7-bromo-4,5-dihydro-5-phenyl-4-propionyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Suppliers and Price of 7-bromo-4,5-dihydro-5-phenyl-4-propionyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 7-bromo-4,5-dihydro-5-phenyl-4-propionyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Chemical Property:

PSA：49.41000
LogP:3.80510

Purity/Quality:: 99% ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of 7-bromo-4,5-dihydro-5-phenyl-4-propionyl-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 5 articles about 7-bromo-4,5-dihydro-5-phenyl-4-propionyl-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 79-03-8
propionyl chloride

: 17972-72-4
7-bromo-5-phenyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]-diazepin-2-one

: 313683-81-7
7-bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201500139

Reference yield:

: 2835-77-0
(2-aminophenyl)(phenyl)methanone

: 313683-81-7
7-bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: dichloromethane; water / 2 h / 0 °C / Inert atmosphere; Alkaline conditions

3: ammonia / methanol / 0 - 20 °C / Inert atmosphere

4: acetic acid; sodium cyanoborohydride / methanol / 6 h / 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With N-Bromosuccinimide; ammonia; sodium cyanoborohydride; acetic acid; triethylamine; In methanol; dichloromethane; water;
DOI:10.1002/cmdc.201500139

Reference yield:

: 39859-36-4
2-amino-5-bromobenzophenone

: 313683-81-7
7-bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane; water / 2 h / 0 °C / Inert atmosphere; Alkaline conditions

2: ammonia / methanol / 0 - 20 °C / Inert atmosphere

3: acetic acid; sodium cyanoborohydride / methanol / 6 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With ammonia; sodium cyanoborohydride; acetic acid; triethylamine; In methanol; dichloromethane; water;
DOI:10.1002/cmdc.201500139