2-Amino-7-methylnaphthalene

Base Information

• Chemical Name: 2-Amino-7-methylnaphthalene
• CAS No.: 116530-25-7
• Molecular Formula: C11H11N
• Molecular Weight: 157.21174
• Mol file: 116530-25-7.mol

Synonyms:2-Amino-7-methylnaphthalene

Chemical Property of 2-Amino-7-methylnaphthalene

Chemical Property:

• Melting Point: 105 °C
• Boiling Point: 324.5±11.0 °C(Predicted)
• PKA: 4.41±0.10(Predicted)
• PSA: 26.02000
• Density: 1.106±0.06 g/cm3(Predicted)
• LogP: 3.31160

Purity/Quality:

95% ^*data from raw suppliers

2-Amino-7-methylnaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-7-methylnaphthalene

There total 8 articles about 2-Amino-7-methylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-methylnaphthalen-2-ol (26593-50-0) → 7-methylnaphthalen-2-amine (116530-25-7)

Guidance literature:

7-methylnaphthalen-2-ol; With 2-bromo-propionic acid amide; potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 50 ℃;

With potassium hydroxide; In dimethyl sulfoxide; at 150 ℃;

Reference yield: 60.0%

7-amino-2-bromo-naphthalene + methylmagnesium chloride (676-58-4) → 7-methylnaphthalen-2-amine (116530-25-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 80 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201710537

Reference yield:

7-bromonaphthalen-2-ol (116230-30-9) → 7-methylnaphthalen-2-amine (116530-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogensulfite; ammonium hydroxide / 48 h / 150 °C / Inert atmosphere; Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; sodium hydrogensulfite; In tetrahydrofuran;

DOI:10.1002/anie.201710537

upstream raw materials:

2-methyl-7-nitronaphthalene

acetic acid

N-(7-methyl-[1]naphthyl)-acetamide

7-methyl-2-nitro-[1]naphthylamine

Refernces

• 1、 Jiang, Qianwen,Liu, Wei,Yang, Xiaoyu. "A Versatile Method for Kinetic Resolution of Protecting-Group-Free BINAMs and NOBINs through Chiral Phosphoric Acid Catalyzed Triazane Formation". supporting information. p. 23598 - 23602. Retrieved 2020/10/23.