1-(benzyloxy)-2-Methylpropan-2-aMine

Base Information

• Chemical Name: 1-(benzyloxy)-2-Methylpropan-2-aMine
• CAS No.: 114377-40-1
• Molecular Formula: C11H17NO
• Molecular Weight: 179.262
• Mol file: 114377-40-1.mol

Synonyms:1-(benzyloxy)-2-Methylpropan-2-aMine

Chemical Property of 1-(benzyloxy)-2-Methylpropan-2-aMine

Chemical Property:

• PSA: 35.25000
• LogP: 2.64080

Purity/Quality:

99% ^*data from raw suppliers

1-(Benzyloxy)-2-methylpropan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(benzyloxy)-2-Methylpropan-2-aMine

There total 5 articles about 1-(benzyloxy)-2-Methylpropan-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl (1-(benzyloxy)-2-methylpropan-2-yl)carbamate → 1-(benzyloxy)-2-methylpropan-2-amine (114377-40-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

benzyl bromide (100-39-0) + 2-Amino-2-methyl-1-propanol (124-68-5) → 1-(benzyloxy)-2-methylpropan-2-amine (114377-40-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

Reference yield:

methylmagnesium bromide (75-16-1) + C10H12NO(1-)*Br(1-)*Mg(2+) → 1-(benzyloxy)-2-methylpropan-2-amine (114377-40-1)

Guidance literature:

With titanium(IV) isopropylate; In toluene; at 25 ℃; Yield given;

DOI:10.1016/S0040-4039(98)00983-6

upstream raw materials:

methylmagnesium bromide

benzyl chloride

2-Amino-2-methyl-1-propanol

benzyl bromide

Downstream raw materials:

(1-benzyloxy-2-methyl)prop-2-ylisocyanate

3-(2-benzyloxy-1,1-dimethyl-ethyl)-2-chloro-[1,3,2]oxazaphosphinane 2-oxide

Refernces

• 1、 -. "OPIOID AGONISTS AND USES THEREOF". Paragraph 00292. . Retrieved 2015/06/11.
• 2、 Charette, Andre B.,Gagnon, Alexandre,Janes, Marc,Mellon, Christophe. "Synthesis of α,α-disubstituted-α-amino acids by double nucleophilic addition to cyanohydrins". . p. 5147 - 5150. Retrieved 2007/10/03.