5,7-Dichloro-2-(3,5-diMethyl-phenyl)-quinoline

Base Information

• Chemical Name: 5,7-Dichloro-2-(3,5-diMethyl-phenyl)-quinoline
• CAS No.: 1436690-90-2
• Molecular Formula: C17H13Cl2N
• Molecular Weight: 302.19782
• Mol file: 1436690-90-2.mol

Synonyms:5,7-Dichloro-2-(3,5-diMethyl-phenyl)-quinoline

Chemical Property of 5,7-Dichloro-2-(3,5-diMethyl-phenyl)-quinoline

Chemical Property:

• PSA: 12.89000
• LogP: 5.82540

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-Dichloro-2-(3,5-diMethyl-phenyl)-quinoline

There total 2 articles about 5,7-Dichloro-2-(3,5-diMethyl-phenyl)-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethylacetophenone (5379-16-8) + (2-amino-4, 6-dichlorophenyl)methanol (1436690-87-7) → 5,7-dichloro-2-(3,5-dimethylphenyl)quinoline (1436690-90-2)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; potassium hydroxide; In toluene; for 18h; Reflux; Dean-Stark;

Reference yield:

2-amino-4,6-dichlorobenzoic acid (20776-63-0) → 5,7-dichloro-2-(3,5-dimethylphenyl)quinoline (1436690-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

2: tris(triphenylphosphine)ruthenium(II) chloride; potassium hydroxide / toluene / 18 h / Reflux; Dean-Stark

With lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; potassium hydroxide; In tetrahydrofuran; toluene;

Reference yield: 41.0%

dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane (657408-07-6) + potassium phosphate monohydrate + Dihydroxy-isobutyl-boran (84110-40-7) + 5,7-dichloro-2-(3,5-dimethylphenyl)quinoline (1436690-90-2) → 2-(3,5-dimethylphenyl)-5,7-diisobutylquinoline (1436690-93-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; toluene;

upstream raw materials:

3,5-dimethylacetophenone

(2-amino-4, 6-dichlorophenyl)methanol

2-amino-4,6-dichlorobenzoic acid

Downstream raw materials:

2-(3,5-dimethylphenyl)-5,7-diisobutylquinoline

Refernces