Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide)

Base Information

• Chemical Name: Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide)
• CAS No.: 167105-80-8
• Molecular Formula: C19H22N2O5
• Molecular Weight: 358.39
• Hs Code.: 2933998350
• Mol file: 167105-80-8.mol

Synonyms:Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide);(±)-5-Benzoyl-2,3-dihydro-N-[2-hydroxy-1,1-bis(hydroxyMethyl)ethyl]-1H-pyrrolizine-1-carboxaMide;Ketoroloc IMpurity E;rac Ketoroloc Tris AMide IMpurity;Ketorolac EP IMpurity E;Ketorolac Related CoMpound A

Chemical Property of Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide)

Chemical Property:

• Boiling Point: 732.0±60.0 °C(Predicted)
• PKA: 13.51±0.20(Predicted)
• PSA: 111.79000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 0.42920
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

racKetorolocTrisAmideImpurity ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: rac Ketoroloc Tris Amide Impurity (Ketorolac EP Impurity E) is an impurity of Ketorolac (K235650). Ketorolac USP Related Compound A.

Technology Process of Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide)

There total 1 articles about Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ketorolac (74103-06-3) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → (2,3-dihydro-1H-pyrrolizin-5-yl)(phenyl)methanone + 5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-one (113502-52-6) + (1-hydroxy-2,3-dihydro-1H-pyrrolizin-5-yl)(phenyl)methanone (154476-25-2) + 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-amide (167105-80-8)

Guidance literature:

With water; at 50 ℃; for 2160h; Product distribution; also as calcium salt, tromethamine salt or in the presence propyl gallate, BHT, EDTA and other additives; other time;

DOI:10.1002/jps.2600841003

upstream raw materials:

Ketorolac

2-amino-2-hydroxymethyl-1,3-propanediol

Refernces