Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol)

Base Information

• Chemical Name: Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol)
• CAS No.: 154476-25-2
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.25900
• Hs Code.: 2933998350
• Mol file: 154476-25-2.mol

Synonyms:Methanone,(2,3-dihydro-1-hydroxy-1H-pyrrolizin-5-yl)phenyl;

Chemical Property of Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol)

Chemical Property:

• Boiling Point: 437.6±35.0 °C(Predicted)
• PKA: 14.73±0.20(Predicted)
• PSA: 42.23000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 2.15620
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Descarboxy1-HydroxyKetorolac ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Descarboxy 1-Hydroxy Ketorolac is an impurity of Ketorolac (K235650), an analgesic and anti-inflammatory agent. Descarboxy 1-Hydroxy Ketorolac (Ketorolac EP Impurity A; Ketorolac USP Related Compound B) is an impurity of Ketorolac (K235650), an analgesic and anti-inflammatory agent.

Technology Process of Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol)

There total 5 articles about Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ketorolac tromethamine → 5-formyl-3H-pyrrolizine-1-carboxylic acid + benzaldehyde (100-52-7) + (1-hydroxy-2,3-dihydro-1H-pyrrolizin-5-yl)(phenyl)methanone (154476-25-2)

Guidance literature:

In water; at 40 ℃; for 360h; Reagent/catalyst; Photolysis;

DOI:10.1002/jms.3351

Reference yield:

ketorolac tromethamine → phenyl(3H-pyrrolizin-5-yl)methanone + (2,3-dihydro-1H-pyrrolizin-5-yl)(phenyl)methanone + (1-hydroxy-2,3-dihydro-1H-pyrrolizin-5-yl)(phenyl)methanone (154476-25-2)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 24h; Temperature;

DOI:10.1002/jms.3351

Reference yield:

Ketorolac (74103-06-3) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → (2,3-dihydro-1H-pyrrolizin-5-yl)(phenyl)methanone + 5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-one (113502-52-6) + (1-hydroxy-2,3-dihydro-1H-pyrrolizin-5-yl)(phenyl)methanone (154476-25-2) + 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-amide (167105-80-8)

Guidance literature:

With water; at 50 ℃; for 2160h; Product distribution; also as calcium salt, tromethamine salt or in the presence propyl gallate, BHT, EDTA and other additives; other time;

DOI:10.1002/jps.2600841003

upstream raw materials:

Ketorolac

2-amino-2-hydroxymethyl-1,3-propanediol