Benzoic acid 4-(acetylamino)phenyl ester

Base Information

• Chemical Name: Benzoic acid 4-(acetylamino)phenyl ester
• CAS No.: 537-52-0
• Molecular Formula: C₁₅H₁₃NO₃
• Molecular Weight: 255.273
• Mol file: 537-52-0.mol

Synonyms:Benzoic acid 4-(acetylamino)phenyl ester;N-[4-(Benzoyloxy)phenyl]acetamide;p-Hydroxyacetanilide benzoate

Chemical Property of Benzoic acid 4-(acetylamino)phenyl ester

Chemical Property:

• Melting Point: 171°C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 398.5°C (rough estimate)
• Density: 1.1654 (rough estimate)
• Water Solubility.: 17mg/L(37 oC)

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid 4-(acetylamino)phenyl ester

There total 5 articles about Benzoic acid 4-(acetylamino)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-acetaminophenol (103-90-2,8055-08-1) + benzaldehyde (100-52-7) → 4-acetamidophenyl benzoate (537-52-0)

Guidance literature:

With bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-1-ium chloride; palladium diacetate; sodium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 100 ℃; for 24h; Sealed tube;

DOI:10.1016/j.tetlet.2011.03.017

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) + benzoic acid anhydride (93-97-0) → 4-acetamidophenyl benzoate (537-52-0)

Guidance literature:

With pyridine; at 100 ℃;

DOI:10.1021/ja01188a025

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) + benzoyl chloride (98-88-4) → 4-acetamidophenyl benzoate (537-52-0)

Guidance literature:

With sodium carbonate;

upstream raw materials:

4-acetaminophenol

benzoyl chloride

benzoic acid anhydride

4-nitro-phenol

Downstream raw materials:

MoO₂(C₆H₅COOC₆H₄N(O)COCH₃)2

4-hydroxy-2-nitroaniline

N-butylbenzamide

4-acetaminophenol