3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- (tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- aMine

Base Information

Chemical Name:3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- (tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- aMine
CAS No.:877399-08-1
Molecular Formula:C19H22BCl2FN2O3
Molecular Weight:427.111
Hs Code.:
Mol file:877399-08-1.mol

Synonyms:3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- (tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- aMine;3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylaMine;3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-AMINE

Suppliers and Price of 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- (tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- aMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Chemenu
3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 95%
1g
$ 605.00

Total 5 raw suppliers

Chemical Property of 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- (tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- aMine

Chemical Property:

PSA：66.60000
LogP:5.13010

Purity/Quality:

98%min ^*data from raw suppliers

3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- (tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- aMine

There total 10 articles about 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5- (tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1331786-34-5
(±)-bis(Boc)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine

: 877399-08-1
(±)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 40 ℃; for 26h;

Reference yield: 60.0%

: 756503-69-2,1448326-33-7,877399-00-3
(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine

: 73183-34-3
bis(pinacol)diborane

: 877399-08-1
(±)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 756520-66-8
1-(2,6-dichloro-3-fluorophenyl)ethanol

: 877399-08-1
(±)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

2: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere

4: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

5: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 12 h / 40 °C / Inert atmosphere

With hydrogenchloride; dmap; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate; iron; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jm2007613