Technology Process of (±)-bis(Boc)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine
There total 6 articles about (±)-bis(Boc)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate;
In
dimethyl sulfoxide;
at 80 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/jm2007613
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
2: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
3: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere
With
dmap; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm2007613
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
2: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
3: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
4: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
5: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere
With
dmap; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate; iron; acetic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
1: Mitsunobu reaction;
DOI:10.1021/jm2007613
