1-Pyrrolidinecarboxaldehyde, 2-(1-hydroxy-1-methylethyl)-, (S)- (9CI)

Base Information

Chemical Name:1-Pyrrolidinecarboxaldehyde, 2-(1-hydroxy-1-methylethyl)-, (S)- (9CI)
CAS No.:129149-57-1
Molecular Formula:C₈H₁₅NO₂
Molecular Weight:157.213
Hs Code.:
Mol file:129149-57-1.mol

Synonyms:1-Pyrrolidinecarboxaldehyde, 2-(1-hydroxy-1-methylethyl)-, (S)- (9CI)

Suppliers and Price of 1-Pyrrolidinecarboxaldehyde, 2-(1-hydroxy-1-methylethyl)-, (S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxaldehyde, 2-(1-hydroxy-1-methylethyl)-, (S)- (9CI)

Chemical Property:

PSA：40.54000
LogP:0.95190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxaldehyde, 2-(1-hydroxy-1-methylethyl)-, (S)- (9CI)

There total 4 articles about 1-Pyrrolidinecarboxaldehyde, 2-(1-hydroxy-1-methylethyl)-, (S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 92053-25-3,214626-52-5
(S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine

: 109-94-4
formic acid ethyl ester

: 129149-57-1
(S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine

Guidance literature:: In dichloromethane; for 48h; Ambient temperature;
DOI:10.1021/ja00175a030

Reference yield:

: 51207-68-2
(2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine

: 129149-57-1
(S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / H₂ / 5percent Pd/C / methanol / 3 h / Ambient temperature

2: 90 percent / CH₂Cl₂ / 48 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ja00175a030

Reference yield:

: 5211-23-4
N-carbobenzyloxy-L-proline methyl ester

: 129149-57-1
(S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / tetrahydrofuran; diethyl ether / 1.) -20 deg C, 0.5 h, 2.) 0 deg C, 1 h

2: 86 percent / H₂ / 5percent Pd/C / methanol / 3 h / Ambient temperature

3: 90 percent / CH₂Cl₂ / 48 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja00175a030