6-azaindole-7-carboxylic acid Methyl ester

Base Information

• Chemical Name: 6-azaindole-7-carboxylic acid Methyl ester
• CAS No.: 945840-73-3
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Mol file: 945840-73-3.mol

Synonyms:6-azaindole-7-carboxylic acid Methyl ester;methyl 1H-pyrrolo[2,3-c]pyridine-7-carboxylate

Chemical Property of 6-azaindole-7-carboxylic acid Methyl ester

Chemical Property:

• PSA: 54.98000
• LogP: 1.34950

Purity/Quality:

97% ^*data from raw suppliers

Methyl1H-pyrrolo[2,3-c]pyridine-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-azaindole-7-carboxylic acid Methyl ester

There total 1 articles about 6-azaindole-7-carboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 7-chloro-1H-pyrrolo[2,3-c]pyridine (357263-41-3) → 1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid methyl ester (945840-73-3)

Guidance literature:

With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In toluene; at 110 ℃; for 17h; under 37503.8 Torr;

Reference yield: 50.0%

(4-tert-butyl-benzyl)-[2-(4-fluoro-3-trifluoromethyl-phenyl)-ethyl]-amine (875305-31-0) + 1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid methyl ester (945840-73-3) → 1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid(4-tert-butyl-benzyl)-[2-(4-fluoro-3-trifluoromethyl-phenyl)-ethyl]-amide

Guidance literature:

(4-tert-butyl-benzyl)-[2-(4-fluoro-3-trifluoromethyl-phenyl)-ethyl]-amine; With trimethylaluminum; In n-heptane; dichloromethane; at 20 ℃; for 0.25h;

1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid methyl ester; In n-heptane; dichloromethane; for 2h;

Reference yield:

1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid methyl ester (945840-73-3) → 1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid (945840-82-4)

Guidance literature:

1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid methyl ester; With potassium hydroxide; water; In tetrahydrofuran; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;

upstream raw materials:

methanol

carbon monoxide

7-chloro-1H-pyrrolo[2,3-c]pyridine

Downstream raw materials:

1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid