2-Chloro-3-phenylsulfonaMidopyridine-5-boronic acid pinacol ester, 96%

Base Information

• Chemical Name: 2-Chloro-3-phenylsulfonaMidopyridine-5-boronic acid pinacol ester, 96%
• CAS No.: 1083326-55-9
• Molecular Formula: C17H22BClN2O5S
• Molecular Weight: 394.687
• Mol file: 1083326-55-9.mol

Synonyms:2-Chloro-3-phenylsulfonaMidopyridine-5-boronic acid pinacol ester, 96%;N-[2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-BENZENESULFONAMIDE

Chemical Property of 2-Chloro-3-phenylsulfonaMidopyridine-5-boronic acid pinacol ester, 96%

Chemical Property:

• PSA: 121.43000
• LogP: 4.50960

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-phenylsulfonamidopyridine-5-boronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-phenylsulfonaMidopyridine-5-boronic acid pinacol ester, 96%

There total 5 articles about 2-Chloro-3-phenylsulfonaMidopyridine-5-boronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-(5-bromo-2-chloropyridin-3-yl)benzenesulfonamide (1083326-17-3) + bis(pinacol)diborane (73183-34-3) → N-[2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]benzenesulfonamide (1083326-55-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113661

Reference yield:

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → N-[2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]benzenesulfonamide (1083326-55-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol; tin(ll) chloride / 1 h / Reflux

2: pyridine / pyridine / 0.67 h / 0 - 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / 110 °C / Microwave irradiation

With pyridine; ethanol; potassium acetate; tin(ll) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; pyridine;

Reference yield:

3-amino-5-bromo-2-chloropyridine (588729-99-1) → N-[2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]benzenesulfonamide (1083326-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / pyridine / 0.67 h / 0 - 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / 110 °C / Microwave irradiation

With pyridine; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; pyridine;

upstream raw materials:

N-(5-bromo-2-chloropyridin-3-yl)benzenesulfonamide

bis(pinacol)diborane

5-bromo-3-nitro-1H-pyridin-2-one

3-amino-5-bromo-2-chloropyridine

Downstream raw materials:

N-(2-chloro-5-{8-[3-(methylsulfonyl)phenyl]-1,5-naphthyridin-2-yl}-3-pyridinyl)benzenesulfonamide

N-{2-chloro-5-[8-(4-pyridinyl)-1,5-naphthyridin-2-yl]-3-pyridinyl}benzenesulfonamide

N-(2-chloro-5-(4-(4-morpholinyl)pyrido[3,2-d]pyrimidin-6-yl)-3-pyridinyl)benzenesulfonamide

N-(2-chloro-5-(4-(tetrahydro-2H-pyran-4-yloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide