1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid
• CAS No.: 1020253-87-5
• Molecular Formula: C₁₀H₇ClN₂O₃
• Molecular Weight: 238.63
• Mol file: 1020253-87-5.mol

Synonyms:1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid

Chemical Property of 1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid

There total 2 articles about 1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorophenylhydrazine hydrochloride (1073-70-7) + dimethyl acetylenedicarboxylate (762-42-5) → 1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid (1020253-87-5)

Guidance literature:

4-chlorophenylhydrazine hydrochloride; dimethyl acetylenedicarboxylate; With triethylamine; In tetrahydrofuran; at 20 ℃;

With sodium methylate; In methanol; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.1016/j.bmcl.2021.127996

Reference yield:

Oxalacetic acid (328-42-7) + N-4-chlorophenylhydrazine (1073-69-4) → 1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid (1020253-87-5)

Guidance literature:

With sulfuric acid; water; at 5 ℃;

DOI:10.1021/jm300663n

Reference yield:

1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid (1020253-87-5) + C9H9Cl2NO2 (682803-48-1) → C19H14Cl3N3O4 (1394179-14-6)

Guidance literature:

1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid; With N-ethylmorpholine;; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

C₉H₉Cl₂NO₂; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm300663n

upstream raw materials:

Oxalacetic acid

N-4-chlorophenylhydrazine

4-chlorophenylhydrazine hydrochloride

dimethyl acetylenedicarboxylate

Downstream raw materials:

C₁₉H₁₄Cl₃N₃O₄