Methyl3-amino-5-(hydroxymethyl)benzoate

Base Information

• Chemical Name: Methyl3-amino-5-(hydroxymethyl)benzoate
• CAS No.: 220286-47-5
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Hs Code.: 2916399090
• Mol file: 220286-47-5.mol

Synonyms:methyl (3-amino)-5-hydroxymethylbenzoate;3-amino-5-hydroxymethylbenzoic acid methyl ester;3-Amino-5-[hydroxymethyl]benzoic acid,methyl ester;methyl 3-amino-5-(hydroxymethyl)benzoate;Methyl 3-amino-5-hydroxymethylbenzoate;

Chemical Property of Methyl3-amino-5-(hydroxymethyl)benzoate

Chemical Property:

• PSA: 72.55000
• LogP: 1.12890

Purity/Quality:

99% ^*data from raw suppliers

Methyl 3-amino-5-(hydroxymethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl3-amino-5-(hydroxymethyl)benzoate

There total 4 articles about Methyl3-amino-5-(hydroxymethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-hydroxymethyl-5-nitrobenzoic acid methyl ester (53732-08-4) → 3-Amino-5-hydroxymethylbenzoic acid methyl ester (220286-47-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; for 8h;

DOI:10.1021/ol401989e

Reference yield: 71.0%

dimethyl 5-aminoisophthalate (99-27-4) → 3-Amino-5-hydroxymethylbenzoic acid methyl ester (220286-47-5)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 0 - 50 ℃; regioselective reaction;

DOI:10.1021/jm2001025

Reference yield:

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester (1955-46-0) + dimethylsulfide borane complex (13292-87-0) → 3-Amino-5-hydroxymethylbenzoic acid methyl ester (220286-47-5)

Guidance literature:

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester; dimethylsulfide borane complex; With sodium chloride; In tetrahydrofuran; for 18h;

With palladium 10% on activated carbon; hydrogen; In ethyl acetate;

upstream raw materials:

3-hydroxymethyl-5-nitrobenzoic acid methyl ester

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

dimethylsulfide borane complex

iron

Downstream raw materials:

3-bromo-5-hydroxymethylbenzoic acid methyl ester

3-azido-5-hydroxymethylbenzoic acid methyl ester

3-azido-5-azidomethylbenzoic acid methyl ester

3-azido-5-(azidomethyl)-benzoic acid