Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride

Base Information

• Chemical Name: Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride
• CAS No.: 42718-18-3
• Molecular Formula: C₉H₁₀FNO₂*ClH
• Molecular Weight: 219.643
• Hs Code.: 2922498590
• Mol file: 42718-18-3.mol

Synonyms:Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride

Chemical Property of Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 2.50080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

methylamino(4-fluorophenyl)acetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride

There total 5 articles about Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (S)-2-amino-2-(4-fluorophenyl)acetic acid (19883-57-9) → (S)-methyl 2-amino-2-(4-fluorophenyl)acetate hydrochloride (916602-09-0,42718-18-3)

Guidance literature:

With thionyl chloride; at 0 - 75 ℃; for 2h;

DOI:10.1016/j.ejmech.2018.01.032

Reference yield: 96.4%

methanol (67-56-1) + (R)-2-(4-fluorophenyl)glycine (93939-74-3) → methyl (R)-2-amino-2-(4-fluorophenyl)acetate hydrochloride (439213-22-6,42718-18-3)

Guidance literature:

With thionyl chloride; at 0 - 75 ℃; for 2h;

DOI:10.1016/j.ejmech.2018.01.032

Reference yield:

methanol (67-56-1) + (S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride (185994-15-4) → (S)-methyl 2-amino-2-(4-fluorophenyl)acetate hydrochloride (916602-09-0,42718-18-3)

Guidance literature:

With hydrogenchloride; for 12h; Reflux;

DOI:10.1002/anie.201309682

upstream raw materials:

methanol

(R)-2-(4-fluorophenyl)glycine

(S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride

(S)-2-amino-2-(4-fluorophenyl)acetic acid

Downstream raw materials:

methyl 2-isocyano-2-(4-fluorophenyl)acetate

methyl 2-(4-fluorophenyl)-2-formamidoacetate

(R)-2-amino-2-(4-fluorophenyl)ethanol

(S)-2-amino-2-(4-fluorophenyl)acetohydrazide

Refernces

• 1、 Zhou, Fang,Zhang, Yao,Xu, Xianfeng,Zhu, Shaolin. "NiH-Catalyzed Remote Asymmetric Hydroalkylation of Alkenes with Racemic α-Bromo Amides". supporting information. p. 1754 - 1758. Retrieved 2019/01/19.
• 2、 Mondal, Milon,Radeva, Nedyalka,Koester, Helene,Park, Ahyoung,Potamitis, Constantinos,Zervou, Maria,Klebe, Gerhard,Hirsch, Anna K. H.. "Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry". supporting information. p. 3259 - 3263. Retrieved 2014/04/03.