7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide
CAS No.:1462950-00-0
Molecular Formula:C₁₄H₁₀FN₃OS₂
Molecular Weight:319.383
Hs Code.:
Mol file:1462950-00-0.mol

Synonyms:7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide

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Chemical Property of 7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide

Chemical Property:

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Technology Process of 7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide

There total 5 articles about 7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1462949-99-0
methyl 7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxylate

: 1462950-00-0
7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 64h;

Reference yield:

: 61727-33-1
5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid

: 1462950-00-0
7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: chloro-trimethyl-silane / dichloromethane / 20 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.25 h / 20 - 60 °C

3: pyridine / 48 h / 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tert-butylimino-tri(pyrrolidino)phosphorane / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5: ammonia / methanol / 64 h / 20 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; chloro-trimethyl-silane; ammonia; sodium hydride; tert-butylimino-tri(pyrrolidino)phosphorane; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 79686-03-6
methyl 5-chloro-2-(methylsulfanyl)pyrimidine-4-carboxylate

: 1462950-00-0
7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.25 h / 20 - 60 °C

2: pyridine / 48 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tert-butylimino-tri(pyrrolidino)phosphorane / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4: ammonia / methanol / 64 h / 20 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonia; sodium hydride; tert-butylimino-tri(pyrrolidino)phosphorane; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;