(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol

Base Information

Chemical Name:(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol
CAS No.:102919-85-7
Molecular Formula:C21H28N2O3
Molecular Weight:356.465
Hs Code.:
DSSTox Substance ID:DTXSID201143186
Mol file:102919-85-7.mol

Synonyms:102919-85-7;102869-99-8;SCHEMBL7883386;MDPFGNLTFZJSEZ-LAKPAKELSA-N;DTXSID201143186;(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol;(5a,6b)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol;17-Cyclopropylmethyl-4,5alpha-epoxy-3,14beta-dihydroxy-6alpha-methylaminomorphinan

Suppliers and Price of (5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol
250 mg
$ 1640.00

Biosynth Carbosynth
(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol
100 mg
$ 901.00

Biosynth Carbosynth
(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol
50 mg
$ 496.00

Biosynth Carbosynth
(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol
25 mg
$ 272.50

Biosynth Carbosynth
(5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol
10 mg
$ 149.90

Total 0 raw suppliers

Chemical Property of (5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol

Chemical Property:

PSA：64.96000
LogP:1.87310
XLogP3:-0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:356.20999276
Heavy Atom Count:26
Complexity:598

Purity/Quality:: (5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O
Isomeric SMILES:CN[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O
Uses Opioid receptor antagonist.

Technology Process of (5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol

There total 6 articles about (5a,6a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 593-51-1
methylamine hydrochloride

: 16590-41-3
Naltrexone

: 102919-85-7
6α-N-methylnaltrexamine

Guidance literature:: methylamine hydrochloride; Naltrexone; With formic acid; triethylamine; [RhCl₂(p-cymene)]2; In acetonitrile; at 23 - 25 ℃; for 24h;

With ammonium hydroxide; In water; pH=9.4;

Reference yield: 6.3%

: 593-51-1
methylamine hydrochloride

: 75768-72-8
naltrexone hydrochloride

: 102869-99-8
6β-N-methylnaltrexamine

: 102919-85-7
6α-N-methylnaltrexamine

Guidance literature:: With sodium cyanoborohydride; In methanol; for 72h;
DOI:10.1021/jm00158a043

Reference yield:

: 16590-41-3
Naltrexone

: 74-89-5
methylamine

: 102869-99-8
6β-N-methylnaltrexamine

: 102919-85-7
6α-N-methylnaltrexamine

Guidance literature:: Naltrexone; methylamine; With hydrogenchloride; sodium cyanoborohydride; In methanol; water; at 20 ℃; for 72h; pH=7;

In methanol; water; pH=1;

With sodium carbonate; In water; pH=9;