1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone

Base Information

• Chemical Name: 1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
• CAS No.: 1453198-89-4
• Molecular Weight: 0
• Mol file: 1453198-89-4.mol

Synonyms:1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone

Chemical Property of 1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone

There total 6 articles about 1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

3-(2,5-dichloropyrimidine-4-yl)-1H-indole (937366-57-9) + N-[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]acetamide (1453198-88-3) → 1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone (1453198-89-4)

Guidance literature:

With toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; pentan-1-ol; at 150 ℃; for 1h;

DOI:10.1021/jm400822z

Reference yield:

1-(4-{3-methoxy-4-nitrophenyl}piperazine-1-yl)ethan-1-one (1116229-11-8) → 1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone (1453198-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1: platinum(IV) oxide; hydrogen / ethanol / 3 h / 25 °C / 975.1 Torr

2: acetic acid / 1 h / 25 °C

3: toluene-4-sulfonic acid / pentan-1-ol; 1-methyl-pyrrolidin-2-one / 1 h / 150 °C

With platinum(IV) oxide; hydrogen; toluene-4-sulfonic acid; acetic acid; In 1-methyl-pyrrolidin-2-one; ethanol; pentan-1-ol;

DOI:10.1021/jm400822z

Reference yield:

1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one (1021426-42-5) → 1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone (1453198-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 1 h / 25 °C

2: toluene-4-sulfonic acid / pentan-1-ol; 1-methyl-pyrrolidin-2-one / 1 h / 150 °C

With toluene-4-sulfonic acid; acetic acid; In 1-methyl-pyrrolidin-2-one; pentan-1-ol;

DOI:10.1021/jm400822z

upstream raw materials:

1-(4-{3-methoxy-4-nitrophenyl}piperazine-1-yl)ethan-1-one

1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one

3-(2,5-dichloropyrimidine-4-yl)-1H-indole

N-[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]acetamide