methyl 3-amino-6-bromo-5-fluoropicolinate

Base Information

• Chemical Name: methyl 3-amino-6-bromo-5-fluoropicolinate
• CAS No.: 1052714-13-2
• Molecular Formula: C7H6BrFN2O2
• Molecular Weight: 249.039
• Mol file: 1052714-13-2.mol

Synonyms:methyl 3-amino-6-bromo-5-fluoropicolinate

Chemical Property of methyl 3-amino-6-bromo-5-fluoropicolinate

Chemical Property:

• Boiling Point: 340.5±37.0 °C(Predicted)
• PSA: 65.21000
• Density: 1.738±0.06 g/cm3(Predicted)
• LogP: 1.93320

Purity/Quality:

98% ^*data from raw suppliers

Methyl3-amino-6-bromo-5-fluoropicolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-amino-6-bromo-5-fluoropicolinate

There total 3 articles about methyl 3-amino-6-bromo-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-amino-5-fluoropyridine-2-carboxylic acid methyl ester (1052714-11-0) → 3-amino-6-bromo-5-fluoropyridine-2-carboxylic acid methyl ester (1052714-13-2)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

3-amino-2-bromo-5-fluoropyridine (884495-03-8) → 3-amino-6-bromo-5-fluoropyridine-2-carboxylic acid methyl ester (1052714-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloro[2,2′ -bis(diphenylphosphino)-1,1′ -binaphthyl]palladium(II) / 6 h / 100 °C / 3102.97 Torr / Inert atmosphere; Sealed tube

2: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C

With N-Bromosuccinimide; triethylamine; dichloro[2,2′ -bis(diphenylphosphino)-1,1′ -binaphthyl]palladium(II); In acetonitrile;

Reference yield:

5-fluoro-3-nitropyridine-2-carbonitrile (1033202-51-5) → 3-amino-6-bromo-5-fluoropyridine-2-carboxylic acid methyl ester (1052714-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(ll) chloride / ethanol / 2 h / 90 °C

1.2: 6 h / Reflux

1.3: 24 h / 90 °C

2.1: N-Bromosuccinimide / acetonitrile / 2 h / 20 - 30 °C

With N-Bromosuccinimide; tin(ll) chloride; In ethanol; acetonitrile;

upstream raw materials:

3-amino-2-bromo-5-fluoropyridine

3-amino-5-fluoropyridine-2-carboxylic acid methyl ester

5-fluoro-3-nitropyridine-2-carbonitrile

Downstream raw materials:

C₃₀H₃₃F₃N₆O₄

3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

3-({[3-amino-6-(2,6-difluorophenyl)-5-fluoropyridin-2-yl]carbonyl}amino)-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

Refernces

• 1、 -. "NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE". . . Retrieved 2021/06/26.
• 2、 -. "FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF". . . Retrieved 2017/08/01.