2-BROMO-2'-METHYLBENZOPHENONE

Base Information

• Chemical Name: 2-BROMO-2'-METHYLBENZOPHENONE
• CAS No.: 294878-57-2
• Molecular Formula: C₁₄H₁₁BrO
• Molecular Weight: 275.145
• Hs Code.: 2914700090
• Mol file: 294878-57-2.mol

Synonyms:2-BROMO-2'-METHYLBENZOPHENONE

Chemical Property of 2-BROMO-2'-METHYLBENZOPHENONE

Chemical Property:

• Vapor Pressure: 0.000107mmHg at 25°C
• Melting Point: 41-43 °C
• Boiling Point: 337.2°C at 760 mmHg
• Flash Point: 51.9°C
• PSA: 17.07000
• Density: 1.375g/cm³
• LogP: 3.98850

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-2'-methylbenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-2'-METHYLBENZOPHENONE

There total 11 articles about 2-BROMO-2'-METHYLBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

o-tolyl magnesium chloride (33872-80-9) + 2-bromobenzoic acid chloride (7154-66-7) → (2-bromophenyl)(o-tolyl)methanone (294878-57-2)

Guidance literature:

o-tolyl magnesium chloride; With zinc(II) chloride; In 1-methyl-pyrrolidin-2-one; diethyl ether; at 60 ℃; for 0.333333h;

2-bromobenzoic acid chloride; ((t-Bu)2POH)2PdCl₂; In 1-methyl-pyrrolidin-2-one; at 25 ℃; for 0.5h; Further stages.;

DOI:10.1021/jo801445y

Reference yield: 76.0%

chloroform (67-66-3,8013-54-5) + 4-iodoanisol (529-28-2) + (2-bromophenyl)boronic acid (244205-40-1) → (2-bromophenyl)(o-tolyl)methanone (294878-57-2)

Guidance literature:

With dmap; palladium diacetate; potassium hydroxide; In chloroform; toluene; at 80 ℃; for 12h;

DOI:10.1021/acs.joc.6b02711

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) + 2-bromobenzoic-acid (88-65-3) → 2-bromophenyl(4-methylphenyl)methanone (67104-64-7) + (2-bromophenyl)(3-methylphenyl)methanone (294878-58-3) + (2-bromophenyl)(o-tolyl)methanone (294878-57-2)

Guidance literature:

With erbium(III) triflate; In neat (no solvent); at 180 ℃; for 0.333333h; Overall yield = 78 %; Microwave irradiation;

DOI:10.1016/j.tetlet.2014.12.038

upstream raw materials:

ortho-tolylmagnesium bromide

o-cyanobromobenzene

o-tolyl magnesium chloride

2-bromobenzoic acid chloride

Refernces

• 1、 Wei, Dong,Hu, Tian-Jiao,Feng, Chen-Guo,Lin, Guo-Qiang. "Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes". supporting information. p. 743 - 748. Retrieved 2018/07/25.
• 2、 Hu, Tian-Jiao,Zhang, Ge,Chen, Ya-Heng,Feng, Chen-Guo,Lin, Guo-Qiang. "Borylation of Olefin C-H Bond via Aryl to Vinyl Palladium 1,4-Migration". . p. 2897 - 2900. Retrieved 2016/03/19.