Technology Process of Phenyl(5,6,7,8-tetrahydronaphthalen-1-yl) ketone
There total 8 articles about Phenyl(5,6,7,8-tetrahydronaphthalen-1-yl) ketone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid; trifluoroacetic anhydride;
at 20 ℃;
for 12h;
Overall yield = 72 %; Overall yield = 127 mg;
Inert atmosphere;
Microwave irradiation;
DOI:10.1016/j.tetlet.2018.01.026
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / H2 / Pd/C / acetic acid / 6 h
2: 87 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
3: 78 percent / MnO2 / CH2Cl2 / 10 h / Heating
4: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 30 min; room temperature, 1 h
5: MnO2 / CH2Cl2 / 10 h / Heating
With
manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(97)10068-0
