2657-20-7

Usage

Uses

Used in Pharmaceutical Industry:
Phenyl(5,6,7,8-tetrahydronaphthalen-2-yl) ketone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures that are essential in drug development. Its versatility in chemical reactions allows for the creation of a wide range of therapeutic agents.
Used in Fragrance Industry:
In the fragrance industry, Phenyl(5,6,7,8-tetrahydronaphthalen-2-yl) ketone is used as a component in the creation of various scents. Its strong aromatic properties make it a valuable addition to the formulation of perfumes and other fragranced products, enhancing the overall aroma profile.
Used in Fine Chemicals Production:
Phenyl(5,6,7,8-tetrahydronaphthalen-2-yl) ketone is utilized as a crucial intermediate in the production of fine chemicals, which are specialty chemicals with high added value. Its role in the synthesis of these compounds is critical for achieving the desired chemical and physical properties in the final products.

InChI:InChI=1/C17H16O/c18-17(14-7-2-1-3-8-14)16-11-10-13-6-4-5-9-15(13)12-16/h1-3,7-8,10-12H,4-6,9H2

Upstream product

• 119-64-2 tetralin 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 91586-31-1 5,6,7,8-tetrahydronaphthalene-2-carbonyl chloride 

Downstream Products

• 107919-21-1 6-(α-chloro-benzyl)-1,2,3,4-tetrahydro-naphthalene 
• 17454-85-2 (1-oxo-3-phenyl-6,7,8,9-tetrahydro-1H-cyclopenta[a]naphthalen-2-yl)-acetic acid 
• 642-29-5 1-benzoylnaphthalene 
• 613-59-2 2-benzylnaphthalene 
• 17497-27-7 [phenyl-(5,6,7,8-tetrahydro-naphthyl-⁽²⁾)-methylene-(seqcis)]-succinic acid 
• 17497-27-7 [phenyl-(5,6,7,8-tetrahydro-naphthyl-⁽²⁾)-methylene-(seqtrans)]-succinic acid 
• 108974-11-4 2-[(1'-hydroxy-1'-phenyl)methyl]-5,6,7,8-tetrahydronaphthalene 
• 35310-85-1 6-benzyl-1,2,3,4-tetrahydronaphthalene 
• 243-17-4 2,3-benzofluorene 
• 205-12-9 benzo[c]fluorene 
• 644-13-3 C₆H₅COC₁₀H₇ 

Relevant academic research and scientific papers

Hydrogen bond donor solvents enabled metal and halogen-free Friedel–Crafts acylations with virtually no waste stream

We have developed a metal and halogen-free Friedel–Crafts acylation protocol with virtually no waste stream generation. We propose a hydrogen bonding donor solvent will form a hydrogen bonding network and may provide significant rate enhancement for Friedel–Crafts reactions. Trifluoroacetic acid is one of the strongest H-bond donor solvents, which is also volatile and can be easily recovered by distillation without need for reaction workup. Our protocol is a ‘green’ Friedel–Crafts acylation process: 1) the catalyst can be recovered and reused; 2) using halogen free starting material (carboxylic acids anhydride or carboxylic acids); 3) no need for aqueous reaction work-up; 4) minimum or no waste steam generation.

Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses

A library of hydrazide derivatives was synthesized to target non-structural protein 1 of influenza A virus (NS1) as a means to develop anti-influenza drug leads. The lead compound 3-hydroxy-N-[(Z)-1-(5,6,7,8-tetrahydronaphthalen-2-yl) ethylideneamino]naphthalene-2-carboxamide, which we denoted as "HENC", was identified by its ability to increase the melting temperature of the effector domain (ED) of the NS1 protein, as assayed using differential scanning fluorimetry. A library of HENC analogs was tested for inhibitory effect against influenza A virus replication in MDCK cells. A systematic diversification of HENC revealed the identity of the R group attached to the imine carbon atom significantly influenced the antiviral activity. A phenyl or cyclohexyl at this position yielded the most potent antiviral activity. The phenyl containing compound had antiviral activity similar to that of the active form of oseltamivir (Tamiflu), and had no detectable effect on cell viability.