4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester
CAS No.:1229516-67-9
Molecular Formula:C₁₃H₂₂N₄O₃
Molecular Weight:282.343
Hs Code.:
Mol file:1229516-67-9.mol

Synonyms:4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester;tert-butyl 4-(4-(hydroxyMethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Suppliers and Price of 4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester

Chemical Property:

PSA：80.48000
Density:1.28
LogP:1.28030

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester

There total 4 articles about 4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 107-19-7
propargyl alcohol

: 180695-80-1
tert-butyl 4-azidopiperidine-1-carboxylate

: 1229516-67-9
tert-butyl 4-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 10h;
DOI:10.1016/j.ejmech.2013.04.045

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1229516-67-9
tert-butyl 4-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol

2: triethylamine / dichloromethane

3: sodium azide / N,N-dimethyl-formamide / 80 °C

4: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 10 h / 20 °C

With sodium tetrahydroborate; copper(l) iodide; sodium azide; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.045

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1229516-67-9
tert-butyl 4-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane

2: sodium azide / N,N-dimethyl-formamide / 80 °C

3: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 10 h / 20 °C

With copper(l) iodide; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.045