16108-48-8

Basic information

• Product Name: Ethyl 2-hydroxy-4,6-diMethylnicotinate
• Synonyms: Ethyl 2-hydroxy-4,6-diMethylnicotinate;ETHYL 4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE;ETHYL 2-HYDROXY-4,6-DIMETHYLPYRIDINE-3-CARBOXYLATE
• CAS NO: 16108-48-8
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.21512
• Mol File: 16108-48-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 371°Cat760mmHg
• Flash Point: 178.2°C
• Appearance: /
• Density: 1.124g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.496
• PKA: 10.30±0.10(Predicted)
• CAS DataBase Reference: Ethyl 2-hydroxy-4,6-diMethylnicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-hydroxy-4,6-diMethylnicotinate(16108-48-8)
• EPA Substance Registry System: Ethyl 2-hydroxy-4,6-diMethylnicotinate(16108-48-8)

Safety Data

• Hazardous Substances Data: 16108-48-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2-hydroxy-4,6-diMethylnicotinate is a chemical compound that belongs to the class of nicotinic acid esters. It is commonly used in the pharmaceutical and cosmetic industries for its anti-inflammatory and vasodilatory properties. Ethyl 2-hydroxy-4,6-diMethylnicotinate is known for its ability to improve skin health by reducing inflammation and promoting blood circulation. It is often utilized in topical formulations for treating skin disorders such as acne, eczema, and psoriasis. Additionally, Ethyl 2-hydroxy-4,6-diMethylnicotinate has shown potential therapeutic effects in the treatment of cardiovascular diseases and metabolic disorders. As with any chemical compound, proper handling and precautions should be taken when using Ethyl 2-hydroxy-4,6-diMethylnicotinate to ensure safety and efficacy.

InChI:InChI=1/C10H13NO3/c1-4-14-10(13)8-6(2)5-7(3)11-9(8)12/h5H,4H2,1-3H3,(H,11,12)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 123-54-6 acetylacetone 
• 124-09-4 1,6-Hexanediamine 
• 54-85-3 isoniazid 
• 622849-35-8 2-ethoxycarbonylmethyl-2-hydroxy-1,4,6-trimethyl-1,2-dihydropyrimidine 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 
• 74-89-5 methylamine 
• 100-46-9 benzylamine 
• 141-43-5 ethanolamine 
• 619-67-0 4-Hydrazinobenzoic acid 
• 100-63-0 phenylhydrazine 
• 1118-66-7 4-Aminopent-3-en-2-one 
• 1068-57-1 acetic acid hydrazide 
• 140-87-4 Cyanoacetohydrazide 

Downstream Products

• 24667-09-2 2-hydroxy-4,6-dimethylnicotinic acid 
• 16115-08-5 6-Hydroxy-2,4-lutidin 
• 1206801-20-8 Ethyl 1-(4-fluorophenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate 
• 113123-58-3 3-ethoxycarbonyl-4,6-dimethyl-1-phenyl-2(1H)-pyridone 
• 339151-88-1 methyl 2-chloro-4,6-dimethylnicotinate 

Relevant articles and documents

Formation of bispyridyl derivatives during the Kost-Sagitullin rearrangement [2]

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Recyclization of intermediates in an enamine rearrangement of a pyrimidinium salt when treated with isoniazide [4]

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PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

Recyclization of pyrimidinium salts into 1,2,4-triazole derivatives

The interaction of the iodomethylates of pyrimidinyl-2-acetic acid derivatives with monosubstituted hydrazines, in addition to the products of a Kost-Sagitullin rearrangement, leads also to N-substituted triazoles. The structure of the triazoles was demonstrated by NOESY NMR experiments. The structure of the reaction products was determined on the basis of the response observed in the spectra between the methyl group protons of the triazole ring and the spatially close proton of the substituent in position 1 and a conclusion was drawn on the direction of the primary attack of nucleophile in the recyclization process of the pyrimidinium salts into a 1,2,4-triazole.