16108-48-8

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-hydroxy-4,6-diMethylnicotinate is used as a therapeutic agent for its potential effects in the treatment of cardiovascular diseases and metabolic disorders. Its vasodilatory properties help in improving blood circulation, which can be beneficial in managing these conditions.
Used in Cosmetic Industry:
Ethyl 2-hydroxy-4,6-diMethylnicotinate is used as an active ingredient in topical formulations for its ability to improve skin health. It is particularly effective in reducing inflammation and promoting blood circulation, making it suitable for treating skin disorders such as acne, eczema, and psoriasis.

InChI:InChI=1/C10H13NO3/c1-4-14-10(13)8-6(2)5-7(3)11-9(8)12/h5H,4H2,1-3H3,(H,11,12)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 123-54-6 acetylacetone 
• 725240-73-3 2,4-dioxo-valeric acid amide 
• 105-53-3 diethyl malonate 
• 1118-66-7 4-amino-3-penten-2-one 
• 7294-89-5 4-(phenylamino)pent-3-en-2-one 
• 75-04-7 ethylamine 
• 124-09-4 1,6-Hexanediamine 
• 3184-13-2 L-ornithine hydrochloride 
• 54-85-3 isoniazid 
• 622849-35-8 2-ethoxycarbonylmethyl-2-hydroxy-1,4,6-trimethyl-1,2-dihydropyrimidine 
• 619-67-0 4-Hydrazinobenzoic acid 
• 100-63-0 phenylhydrazine 
• 1118-66-7 4-Aminopent-3-en-2-one 

Downstream Products

• 24667-09-2 2-hydroxy-4,6-dimethylnicotinic acid 
• 16115-08-5 6-Hydroxy-2,4-lutidin 
• 339151-88-1 methyl 2-chloro-4,6-dimethylnicotinate 
• 113123-58-3 3-ethoxycarbonyl-4,6-dimethyl-1-phenyl-2(1H)-pyridone 
• 1206801-20-8 Ethyl 1-(4-fluorophenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS OF USE

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET

The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.

Recyclization of pyrimidinium salts into 1,2,4-triazole derivatives

The interaction of the iodomethylates of pyrimidinyl-2-acetic acid derivatives with monosubstituted hydrazines, in addition to the products of a Kost-Sagitullin rearrangement, leads also to N-substituted triazoles. The structure of the triazoles was demonstrated by NOESY NMR experiments. The structure of the reaction products was determined on the basis of the response observed in the spectra between the methyl group protons of the triazole ring and the spatially close proton of the substituent in position 1 and a conclusion was drawn on the direction of the primary attack of nucleophile in the recyclization process of the pyrimidinium salts into a 1,2,4-triazole.

Intermediates in the transformation of 1,2-dialkylpyrimidinium iodides in the Kost-Sagitullin rearrangement

Intermediate recyclization products were obtained in a study of the Kost-Sagitullin rearrangement of a series of 1,2-dialkylpyrimidinium iodides. The initial attack of the nucleophile leads to the formation of products of the addition of the hydroxyl group, namely, the corresponding pseudo bases. Heating one of these intermediates in ethanol or in the presence of primary amines leads to rearrangement to give a pyridone derivative. Upon heating in chloroform, the pseudo bases readily lose a water molecule and are converted to anhydro bases, namely, derivatives of 1-alkyl-1,2-dihydro-2-methylidenepyrimidine.

Novel route for the transformation of a pyrimidine ring using hydrazides

It has been shown from X-ray structural analytical data that the reaction of 2-ethoxycarbonylmethyl-1,4,6-trimethylpyrimidinium iodide with carboxylic acid hydrazides gives pyrazolo[1,5-a]pyrimidine derivatives and not the isomeric triazolo[4,3-a]pyridines previously reported. This novel and previously unreported rearrangement of 1,2-dialkylpyrimidinium salts occurs via recyclization of the pyrimidine ring with inclusion of a fragment of the nucleophilic reagent into the transformation product. 2006 Springer Science+Business Media, Inc.

Synthesis of nicotinic acid derivatives by the reaction of salts of 1-alkyl-4,6-dimethyl-2-pyrimidinylacetic acid esters with amines

A study was carried out on the enamine rearrangement of iodoalkylates of the ethyl ester of 4,6-dimethyl-2-pyrimidinylacetic acid to give ethyl esters of 2-alkylamino-4,6-dimethylnicotinic acid, which proceeds upon the action of various amines. The reaction with amines containing an alkyl substituent different from that at the quaternized nitrogen atom of the pyrimidinium salt leads to the formation of products of rearrangement and transamination. In the presence of water, the rearrangement is accompanied by the formation of the ethyl ester of 1,2-dihydro-2-oxo-4,6-dimethylnicotinic acid.