2-amino-5-fluoro-N-methylbenzamide

Base Information

• Chemical Name: 2-amino-5-fluoro-N-methylbenzamide
• CAS No.: 773846-62-1
• Molecular Formula: C8H9FN2O
• Molecular Weight: 168.171
• Hs Code.: 2924299090
• Mol file: 773846-62-1.mol

Synonyms:2-amino-5-fluoro-N-methylbenzamide;4-Fluoro-2-(methylcarbamoyl)aniline, 4-Fluoro-2-[(methylamino)carbonyl]aniline

Chemical Property of 2-amino-5-fluoro-N-methylbenzamide

Chemical Property:

• PSA: 58.61000
• LogP: 1.92350

Purity/Quality:

2-Amino-5-fluoro-N-methylbenzamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-5-fluoro-N-methylbenzamide

There total 6 articles about 2-amino-5-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-fluoro-N-methyl-2-nitrobenzoic acid (878160-05-5) → 2-amino-5-fluoro-N-methylbenzamide (773846-62-1)

Guidance literature:

With hydrogen; palladium on activated carbon; In ethanol; at 20 ℃; for 16h;

Reference yield: 86.0%

2-amino-5-fluorobenzoic acid (446-08-2) + methylamine hydrochloride (593-51-1) → 2-amino-5-fluoro-N-methylbenzamide (773846-62-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1039/d0ob00866d

Reference yield: 65.0%

5-fluoroisatoic anhydride (321-69-7) + methylamine (74-89-5) → 2-amino-5-fluoro-N-methylbenzamide (773846-62-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

5-fluoro-N-methyl-2-nitrobenzoic acid

5-fluoroisatoic anhydride

methylamine

2-amino-5-fluorobenzoic acid

Downstream raw materials:

diethyl (4-{[4-{[4-fluoro-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

Refernces

• 1、 Garad, Dnyaneshwar N.,Mhaske, Santosh B.. "Diversification of quinazolinones by Pd-catalyzed C(sp3)-acetoxylation". . p. 10470 - 10478. Retrieved 2018/05/31.
• 2、 -. "PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK". Page/Page column 15. . Retrieved 2010/05/13.