Dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malonate

Base Information

Chemical Name:Dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malonate
CAS No.:477859-76-0
Molecular Formula:C11H9ClF3NO4
Molecular Weight:311.645
Hs Code.:2933399090
DSSTox Substance ID:DTXSID90363414
Wikidata:Q82147098
ChEMBL ID:CHEMBL1445120
Mol file:477859-76-0.mol

Synonyms:477859-76-0;dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malonate;2-[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINYL]-MALONIC ACID DIMETHYL ESTER;dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propanedioate;Dimethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)malonate;Dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate;HMS2695A16;MLS000706884;CHEMBL1445120;SCHEMBL20333511;DTXSID90363414;MFCD02186504;AKOS005080866;CS-10591;SMR000335718;D93281;12M-726;Dimethyl2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)malonate;2-(3-chloro-5-trifluoromethylpyridinyl)malonic acid dimethyl ester;dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]propanedioate;1,3-dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propanedioate

Suppliers and Price of Dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate >95%
1g
$ 325.00

American Custom Chemicals Corporation
DIMETHYL 2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]MALONATE 95.00%
5MG
$ 623.82

American Custom Chemicals Corporation
DIMETHYL 2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]MALONATE 95.00%
10MG
$ 618.50

American Custom Chemicals Corporation
DIMETHYL 2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]MALONATE 95.00%
1MG
$ 586.97

Total 2 raw suppliers

Chemical Property of Dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malonate

Chemical Property:

Boiling Point:299.6±35.0 °C(Predicted)
PKA:8.25±0.46(Predicted)
PSA：65.49000
Density:1.428±0.06 g/cm3(Predicted)
LogP:2.18340
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:311.0172199
Heavy Atom Count:20
Complexity:361

Purity/Quality:

99% ^*data from raw suppliers

Dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(C1=C(C=C(C=N1)C(F)(F)F)Cl)C(=O)OC

Technology Process of Dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malonate

There total 1 articles about Dimethyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 108-59-8
malonic acid dimethyl ester

: 477859-76-0
1,3-dimethyl 2-(3-chloro-5-trifluoromethylpyridine)malonate

Guidance literature:: 2,3-dichloro-5-trifluoromethylpyridine; With sodium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 1.9h;

malonic acid dimethyl ester; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Temperature;