Kojic Acid

Base Information

• Chemical Name: Kojic Acid
• CAS No.: 123712-78-7
• Molecular Formula: C₆H₆O₄
• Molecular Weight: 142.111
• Mol file: 123712-78-7.mol

Synonyms:

Chemical Property of Kojic Acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Kojic Acid

There total 17 articles about Kojic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-acetoxy-2-acetoxymethyl-4H-pyran-4-one (26209-93-8) → 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7)

Guidance literature:

With sodium methylate; In methanol; for 1h;

DOI:10.1039/c9cc07405h

Reference yield: 78.0%

chlorokojic acid (7559-81-1,54839-86-0) + acetone (67-64-1) → allomaltol (644-46-2) + 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) + iodokojic acid (16065-34-2) + iodoacetone (3019-04-3)

Guidance literature:

With sodium iodide; at 45 ℃; for 24h;

DOI:10.1007/s007060070106

Reference yield: 70.0%

5-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-2-(((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)methyl)-4H-pyran-4-one → 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7)

Guidance literature:

With silica gel; In methanol; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c8cc08841a

upstream raw materials:

D-xylose

mannitol

D-sorbitol

D-galactitol

Downstream raw materials:

C₁₅H₁₂O₃

C₂₃H₁₈N₂O₆

C₂₅H₂₂N₂O₆

C₂₅H₂₂N₂O₅

Refernces

• 1、 Chittenden. "-". . p. 424,426. Retrieved 1969.
• 2、 Lassfolk, Robert,Suonpa?, Anu,Birikh, Klara,Leino, Reko. "Chemo-enzymatic three-step conversion of glucose to kojic acid". supporting information. p. 14737 - 14740. Retrieved 2019/12/23.
• 3、 Uher, Michal,Szymońska, Joanna,Korenova, Anna,Tomasik, Piotr. "Re-examination of nucleophilic substitution in chlorokojic acid". . p. 301 - 307. Retrieved 2007/10/03.