Tert-butyl 2-((methoxycarbonyl)methyl)benzylcarbamate

Base Information

Chemical Name:Tert-butyl 2-((methoxycarbonyl)methyl)benzylcarbamate
CAS No.:147410-31-9
Molecular Formula:C15H21NO4
Molecular Weight:279.336
Hs Code.:
DSSTox Substance ID:DTXSID40701564
Wikidata:Q82633275
Mol file:147410-31-9.mol

Synonyms:147410-31-9;TERT-BUTYL 2-((METHOXYCARBONYL)METHYL)BENZYLCARBAMATE;Methyl 2-(2-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetate;SCHEMBL5841647;DTXSID40701564;QGIIJVCXDSQLMQ-UHFFFAOYSA-N;METHYL 2-(2-((TERT-BUTOXYCARBONYLAMINO)METHYL)PHENYL)ACETATE;MFCD09909446;AB54737;METHYL 2-(2-(N-BOC-AMINOMETHYL)PHENYL)ACETATE;Methyl (2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)acetate;Methyl2-(2-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetate;[2-(tert-butoxycarbonylamino-methyl)-phenyl]-acetic acid methyl ester

Suppliers and Price of Tert-butyl 2-((methoxycarbonyl)methyl)benzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl2-(2-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetate 95+%
1g
$ 371.00

American Custom Chemicals Corporation
METHYL-2-(2-((TERT-BUTOXYCARBONYLAMINO)METHYL)PHENYL)ACETATE 95.00%
5MG
$ 504.67

Alichem
Tert-butyl2-((methoxycarbonyl)methyl)benzylcarbamate
5g
$ 1766.10

Total 2 raw suppliers

Chemical Property of Tert-butyl 2-((methoxycarbonyl)methyl)benzylcarbamate

Chemical Property:

PSA：68.12000
LogP:2.63120
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:279.14705815
Heavy Atom Count:20
Complexity:335

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-(2-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC1=CC=CC=C1CC(=O)OC

Technology Process of Tert-butyl 2-((methoxycarbonyl)methyl)benzylcarbamate

There total 6 articles about Tert-butyl 2-((methoxycarbonyl)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 208124-61-2
(2-aminomethyl-phenyl)-acetic acid methyl ester hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: 147410-31-9
methyl 2-(N-(tert-butoxycarbonyl)aminomethyl)phenylacetate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 18698-97-0
ortho-bromophenylacetic acid

: 147410-31-9
methyl 2-(N-(tert-butoxycarbonyl)aminomethyl)phenylacetate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄ / Heating

2: dimethylformamide / Heating

3: H₂; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr

4: Et₃N / tetrahydrofuran / 25 °C

With hydrogenchloride; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.03.020

Reference yield:

: 57486-69-8
methyl 2-(2-bromophenyl)acetate

: 147410-31-9
methyl 2-(N-(tert-butoxycarbonyl)aminomethyl)phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / Heating

2: H₂; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr

3: Et₃N / tetrahydrofuran / 25 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.03.020