BUTTPARK 19\02-21

Base Information

• Chemical Name: BUTTPARK 19\02-21
• CAS No.: 182554-22-9
• Molecular Formula: C₁₆H₉F₃N₂S
• Molecular Weight: 318.322
• Mol file: 182554-22-9.mol

Synonyms:BUTTPARK 19\02-21;2-PHENYL-7-(TRIFLUOROMETHYL)IMIDAZO[2,1-B]BENZOTHIAZOLE

Chemical Property of BUTTPARK 19\02-21

Chemical Property:

• Boiling Point: 413.0±45.0 °C(Predicted)
• PKA: 4.54±0.40(Predicted)
• PSA: 45.54000
• Density: 1.44±0.1 g/cm3(Predicted)
• LogP: 5.23480

Purity/Quality:

97% ^*data from raw suppliers

2-PHENYL-7-(TRIFLUOROMETHYL)IMIDAZO[2,1-B]BENZOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BUTTPARK 19\02-21

There total 1 articles about BUTTPARK 19\02-21 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-amino-6-trifluoromethyl-1,3-benzothiazole (777-12-8) + α-bromoacetophenone (70-11-1) → 2-phenyl-7-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole (182554-22-9)

Guidance literature:

In ethanol; for 8h; Heating;

Reference yield: 65.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) + 2-phenyl-7-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole (182554-22-9) → Dimethyl-(2-phenyl-7-trifluoromethyl-benzo[d]imidazo[2,1-b]thiazol-3-ylmethyl)-amine (182554-26-3)

Guidance literature:

With acetic acid; In 1,4-dioxane; water; 1.) r.t., 1 h, 2.) 80 deg C, 5 h;

Reference yield:

di-isopropyl azodicarboxylate (2446-83-5) + 2-phenyl-7-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole (182554-22-9) → C24H23F3N4O4S

Guidance literature:

In acetonitrile; at 80 ℃; regioselective reaction; Sealed tube;

DOI:10.1039/c6ra15418b

upstream raw materials:

2-amino-6-trifluoromethyl-1,3-benzothiazole

α-bromoacetophenone

Downstream raw materials:

Dimethyl-(2-phenyl-7-trifluoromethyl-benzo[d]imidazo[2,1-b]thiazol-3-ylmethyl)-amine

(2-Phenyl-7-trifluoromethyl-benzo[d]imidazo[2,1-b]thiazol-3-yl)-acetonitrile

Refernces

• 1、 Palagiano,Arenare,De Caprariis,Grandolini,Ambrogi,Perioli,Filippelli,Falcone,Rossi. "Synthesis and SAR study of imidazo[2,1-b]benzothiazole acids and some related compounds with anti-inflammatory and analgesic activities". . p. 483 - 491. Retrieved 2007/10/03.