4'-CHLORO-2-IODOBENZOPHENONE

Base Information

• Chemical Name: 4'-CHLORO-2-IODOBENZOPHENONE
• CAS No.: 99847-66-2
• Molecular Formula: C₁₃H₈ClIO
• Molecular Weight: 342.563
• Mol file: 99847-66-2.mol

Synonyms:4'-CHLORO-2-IODOBENZOPHENONE;UKRORGSYN-BB BBV-5118692;(4-chlorophenyl)(2-iodophenyl)methanone

Chemical Property of 4'-CHLORO-2-IODOBENZOPHENONE

Chemical Property:

• Vapor Pressure: 2.27E-07mmHg at 25°C
• Boiling Point: 423.2°C at 760 mmHg
• Flash Point: 209.8°C
• PSA: 17.07000
• Density: 1.699g/cm³
• LogP: 4.17560

Purity/Quality:

97% ^*data from raw suppliers

4'-Chloro-2-iodobenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-CHLORO-2-IODOBENZOPHENONE

There total 8 articles about 4'-CHLORO-2-IODOBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-Iodobenzoic acid (88-67-5) + chlorobenzene (108-90-7) → 4-chlorophenyl 2-iodophenyl ketone (99847-66-2)

Guidance literature:

2-Iodobenzoic acid; With thionyl chloride; at 80 ℃; for 24h; Inert atmosphere;

chlorobenzene; With aluminum (III) chloride; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201301599 DOI:10.1002/ejoc.201301599

Reference yield:

2-amino-4'-chlorobenzophenone (2894-51-1) → 4-chlorophenyl 2-iodophenyl ketone (99847-66-2)

Guidance literature:

With toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In water; acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c6cc07394h

Reference yield:

anthranilic acid N-methoxy-N-methylamide (133776-41-7) → 4-chlorophenyl 2-iodophenyl ketone (99847-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / water; acetonitrile / 2 h / 25 °C

With n-butyllithium; toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In tetrahydrofuran; hexane; water; acetonitrile;

DOI:10.1021/acs.orglett.8b01812

upstream raw materials:

2-Iodobenzoic acid

chlorobenzene

2-amino-4'-chlorobenzophenone

anthranilic acid N-methoxy-N-methylamide

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