Methyl salicylate

Base Information

• Chemical Name: Methyl salicylate
• CAS No.: 8024-54-2
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 152.15
• Mol file: 8024-54-2.mol

Synonyms:7631-93-8 (Hydrochloride salt);Ai3-00090

Chemical Property of Methyl salicylate

Chemical Property:

• Vapor Pressure: 0.0296mmHg at 25°C
• Melting Point: 19.4℃
• Boiling Point: 237.2°C at 760 mmHg
• Flash Point: 106.7°C
• PSA: 46.53000
• Density: 0.974g/cm³
• LogP: 1.17880
• Water Solubility.: 0.07 g/100 mL (20℃)

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn:Harmful
• Statements: R22:; R36/38:
• Safety Statements: S24/25:

MSDS Files:

Useful:

Technology Process of Methyl salicylate

There total 155 articles about Methyl salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Methyl 2-<(3,4-Dimethoxyphenyl)methoxy>benzoate (73119-94-5) → veratryl acetate (53751-40-9) + methyl salicylate (119-36-8,8024-54-2)

Guidance literature:

With acetic acid; at 90 ℃; for 4h;

DOI:10.1080/00397919408011711

Reference yield: 67.0%

2-methoxybenzoic acid methyl ester (606-45-1) → salicylic acid (69-72-7,25496-36-0,8052-31-1) + methyl salicylate (119-36-8,8024-54-2)

Guidance literature:

With iodine; aluminium; In cyclohexane; at 45 ℃; for 1h; Solvent; Temperature;

DOI:10.1016/j.tetlet.2018.03.010

Reference yield: 65.0%

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → methyl 2-oxepinecarboxylate (67490-10-2) + benzyl alcohol (100-51-6,185532-71-2) + methyl salicylate (119-36-8,8024-54-2)

Guidance literature:

With Phellinus ribis Karst var. ribis (NCWRF-FPRL 42); at 20 ℃;

DOI:10.1039/b718375e

upstream raw materials:

diazomethane

diethyl ether

salicylic acid

methanol

Downstream raw materials:

salicylic acid tetrahydropyran-2-ylmethyl ester

6'-hydroxy-2,3'-carbonyl-di-benzoic acid

2-(N,N-phthaloyl-glycyloxy)-benzoic acid methyl ester

methyl (±)-2-(2,3-dihydroxypropoxy)benzoate

Refernces

• 1、 Alsaif, Nawaf A.,Taghour, Mohammed S.,Alanazi, Mohammed M.,Obaidullah, Ahmad J.,Al-Mehizia, Abdulrahman A.,Alanazi, Manal M.,Aldawas, Saleh,Elwan, Alaa,Elkady, Hazem. "Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers". . p. 1093 - 1114. Retrieved 2021/06/11.
• 2、 Nguyen, Ngoc-Hong,Vo, Van-Giau,Phan, Hoang-Vinh-Truong,Ngo, Thanh-The,Sichaem, Jirapast,Nguyen, Thi-Phuong,Nguyen, Huu-Hung,Pham, Duc-Dung,Nguyen, Tien-Cong,Nguyen, Van-Kieu,Duong, Thuc-Huy. "Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents". supporting information. p. 371 - 378. Retrieved 2020/07/13.