METHYL 1,3-BENZOXAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1,3-BENZOXAZOLE-5-CARBOXYLATE
• CAS No.: 924869-17-0
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.159
• Hs Code.: 2934999090
• Mol file: 924869-17-0.mol

Synonyms:METHYL 1,3-BENZOXAZOLE-5-CARBOXYLATE;Methyl benzo[d]oxazole-5-carboxylate;5-(Methoxycarbonyl)-1,3-benzoxazole, 5-(Methoxycarbonyl)benzo[d]oxazole;Methyl 5-Benzoxazolecarboxylate;5-(Methoxycarbonyl)benzoxazole;5-Benzoxazolecarboxylic acid methyl ester;Methyl benzoxazole-5-carboxylate

Chemical Property of METHYL 1,3-BENZOXAZOLE-5-CARBOXYLATE

Chemical Property:

• Melting Point: 110-111
• PSA: 52.33000
• LogP: 1.61440
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl1,3-benzoxazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1,3-BENZOXAZOLE-5-CARBOXYLATE

There total 8 articles about METHYL 1,3-BENZOXAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 3-amino-4-hydroxybenzoate (536-25-4) + trimethyl orthoformate (149-73-5) → benzoxazole-5-carboxylic acid methyl ester (924869-17-0)

Guidance literature:

at 160 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/acs.jnatprod.9b00072

Reference yield:

methanol (67-56-1) + trimethyl orthoformate (149-73-5) + 3-amino-4-hydroxybenzoic acid (1571-72-8) → benzoxazole-5-carboxylic acid methyl ester (924869-17-0)

Guidance literature:

methanol; 3-amino-4-hydroxybenzoic acid; With hydrogenchloride; In water; at 80 ℃; for 12h;

trimethyl orthoformate; In water; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

orthoformic acid triethyl ester (122-51-0) + methyl 3-amino-4-hydroxybenzoate (536-25-4) → benzoxazole-5-carboxylic acid methyl ester (924869-17-0)

Guidance literature:

With toluene-4-sulfonic acid; at 140 ℃;

DOI:10.1021/ol101450u

upstream raw materials:

methyl 3-amino-4-hydroxybenzoate

formic acid

orthoformic acid triethyl ester

methanol

Downstream raw materials:

C₁₅H₁₂N₂O₂

C₁₄H₉ClN₂O₂

C₁₅H₁₂N₂O₃

C₁₄H₉N₃O₄