4-PyridineMethanol, 3,5-dichloro-α-Methyl-

Base Information

• Chemical Name: 4-PyridineMethanol, 3,5-dichloro-α-Methyl-
• CAS No.: 1254473-66-9
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.04
• Hs Code.: 2933399990
• Mol file: 1254473-66-9.mol

Synonyms:4-PyridineMethanol, 3,5-dichloro-α-Methyl-

Chemical Property of 4-PyridineMethanol, 3,5-dichloro-α-Methyl-

Chemical Property:

• Boiling Point: 276.1±35.0 °C(Predicted)
• PKA: 12.16±0.20(Predicted)
• PSA: 33.12000
• Density: 1.395±0.06 g/cm3(Predicted)
• LogP: 2.44170
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(3,5-Dichloropyridin-4-yl)ethanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PyridineMethanol, 3,5-dichloro-α-Methyl-

There total 2 articles about 4-PyridineMethanol, 3,5-dichloro-α-Methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-dichloropyridine (2457-47-8) + acetaldehyde (75-07-0,9002-91-9) → 1-(3,5-dichloropyridin-4-yl)ethan-1-ol (1254473-66-9,1254473-68-1)

Guidance literature:

3,5-dichloropyridine; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexanes; at -78 ℃;

acetaldehyde; In tetrahydrofuran; hexanes; at -78 ℃; for 3h;

With water; ammonium chloride; In tetrahydrofuran; hexanes; at -78 ℃;

Reference yield: 61.0%

methylmagnesium chloride (676-58-4) + 3,5-dichloropyridine-4-carboxaldehyde (136590-83-5) → 1-(3,5-dichloropyridin-4-yl)ethan-1-ol (1254473-66-9,1254473-68-1)

Guidance literature:

methylmagnesium chloride; 3,5-dichloropyridine-4-carboxaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran; Cooling with ice;

Reference yield: 85.0%

1-(3,5-dichloropyridin-4-yl)ethan-1-ol (1254473-66-9,1254473-68-1) → methyl 3,5-dichloro-4-pyridyl ketone (402561-66-4)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 10h;

upstream raw materials:

3,5-dichloropyridine

acetaldehyde

methylmagnesium chloride

3,5-dichloropyridine-4-carboxaldehyde

Downstream raw materials:

(S)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol

methyl 3,5-dichloro-4-pyridyl ketone

C₁₅H₁₄ClN₃O

C₂₁H₂₆N₄O

Refernces

• 1、 Yan, Wei,Wang, Xinyi,Dai, Yang,Zhao, Bin,Yang, Xinying,Fan, Jun,Gao, Yinglei,Meng, Fanwang,Wang, Yuming,Luo, Cheng,Ai, Jing,Geng, Meiyu,Duan, Wenhu. "Discovery of 3-(5′-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation". supporting information. p. 6690 - 6708. Retrieved 2016/08/06.
• 2、 -. "CRYSTALLINE (R)-(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL". Page/Page column 1-2. . Retrieved 2012/04/11.