402561-66-4

Basic information

• Product Name: 1-(3,5-dichloropyridin-4-yl)ethanone
• Synonyms: 1-(3,5-dichloropyridin-4-yl)ethanone;1-(3,5-dichloropyridin-4-yl)ethan-1-one;1-(3,5-Dichloro-4-pyridinyl)ethanone
• CAS NO: 402561-66-4
• Molecular Formula: C7H5Cl2NO
• Molecular Weight: 190.0267
• Mol File: 402561-66-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 210.5°C at 760 mmHg
• Flash Point: 81.1°C
• Appearance: /
• Density: 1.376g/cm³
• Vapor Pressure: 0.192mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-(3,5-dichloropyridin-4-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-dichloropyridin-4-yl)ethanone(402561-66-4)
• EPA Substance Registry System: 1-(3,5-dichloropyridin-4-yl)ethanone(402561-66-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 402561-66-4(Hazardous Substances Data)

Usage

General Description

1-(3,5-dichloropyridin-4-yl)ethanone, also known as 2-chloro-n-(3,5-dichloropyridin-4-yl)acetamide, is a chemical compound featuring a pyridine ring, which is a basic aromatic six-membered ring with one nitrogen atom. This specific compound is substituted with chlorine atoms at the 3 and 5 positions while also containing an ethanone side group on the 1 position of the ring. It's utilized in the production of various organic products. As with many chemical substances, it needs to be properly handled and stored to ensure safety. However, specific properties such as its melting point, boiling point, density, and potential hazards or toxicity aren't directly specified, meaning further details may require additional research or consultation.

InChI:InChI=1/C7H5Cl2NO/c1-4(11)7-5(8)2-10-3-6(7)9/h2-3H,1H3

Upstream product

• 2457-47-8 3,5-dichloropyridine 
• 1254473-66-9 1-(3,5-dichloropyridin-4-yl)ethan-1-ol 
• 136590-83-5 3,5-dichloropyridine-4-carboxaldehyde 
• 153463-65-1 3,5-dichloropyridine-4-carbonitrile 
• 402561-62-0 methyl 3,5-dichloro-4-pyridyl imine 

Downstream Products

• 1254473-68-1 (R)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol 
• 1370347-50-4 (S)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol 

Relevant articles and documents

A chiral 1 - (3,5- two chloropyridine -4-yl)-ethanol synthesis method

The invention discloses an asymmetric synthesis method of 1-(3,5-dichloropyridine-4-yl)-ethanol. The asymmetric synthesis method comprises the following steps: (A) under an action of lithium amide, carrying out a reaction of 3,5-dichloropyridine (I) with acetaldehyde to generate (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol (II); (B) under an action of an oxidant, allowing (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol (II) to generate 1-(3,5-dichloropyridine-4-yl)-ethyl ketone (III); and (C) in the presence of a chiral ligand, carrying out a reaction of 1-(3,5-dichloropyridine-4-yl)-ethyl ketone with a borane reagent, and thus obtaining the 1-(3,5-dichloropyridine-4-yl)-ethanol (IV) having a single optical isomer. Compared with traditional chiral column separation of (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol, the method has the prominent advantages that: (1) the reactions are simple, the operation is easy, the total yield is high, and the optical purity is more than 98%; (2) the industrial preparation period is shortened obviously, and equipment requirements are low; and (3) the preparation cost is low, and the method is suitable for industrial production.

3,5-Dichloro-4-pyridinecarbonitrile: A multisite substrate for carbon nucleophiles

The reactivity of 3,5-dichloro-4-pyridinecarbonitrile (1) towards lithium or magnesium organometallic reagent is described. Conditions for substitution of cyano with alkyl or phenyl group, alkylation at the position 2 with removal of the 5-positioned chlorine, and formation of methyl or phenyl dichloropyridyl imines are reported. The obtained 4-alkyl-3,5-dichloropyridines can undergo a further alkylation at the position 2. The 3,5-dichloro-4-pyridyl residue is shown to be a good leaving group in form of anion yielding 3,5-dichloropyridine either from 1 or 3,5-dichloro-4-pyridinecarboxaldehyde.