(4-BROMO-PHENYL)-METHYL-AMINE HYDROCHLORIDE

Base Information

• Chemical Name: (4-BROMO-PHENYL)-METHYL-AMINE HYDROCHLORIDE
• CAS No.: 84250-73-7
• Molecular Formula: C7H9BrClN
• Molecular Weight: 222.51
• Hs Code.: 2921420090
• Mol file: 84250-73-7.mol

Synonyms:(4-BROMO-PHENYL)-METHYL-AMINE HYDROCHLORIDE;4-Bromo-N-methylaniline, HCl;4-BroMo-N-Methylaniline hydrochloride

Chemical Property of (4-BROMO-PHENYL)-METHYL-AMINE HYDROCHLORIDE

Chemical Property:

• PSA: 12.03000
• LogP: 3.36580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥95% ^*data from raw suppliers

4-Bromo-N-methylanilineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-BROMO-PHENYL)-METHYL-AMINE HYDROCHLORIDE

There total 2 articles about (4-BROMO-PHENYL)-METHYL-AMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-bromo-aniline (106-40-1) → 4-bromo-N-methylaniline hydrochloride (84250-73-7)

Guidance literature:

formaldehyd; 4-bromo-aniline; With hydrogen; In tetrahydrofuran; at 120 ℃; for 9h; under 3750.38 Torr; Autoclave;

With hydrogenchloride; In water;

DOI:10.1039/c7cc02314f

Reference yield: 68.0%

N-(4-bromophenyl)formamide (2617-78-9) → 4-bromo-N-methylaniline hydrochloride (84250-73-7)

Guidance literature:

N-(4-bromophenyl)formamide; With tris((4,4-dimethyl-2-oxazolinyl)phenylborate) MgMe; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane;

With hydrogenchloride;

DOI:10.1021/acscatal.5b01038

Reference yield:

carbon monoxide (201230-82-2) + 4-bromo-N-methylaniline hydrochloride (84250-73-7) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → N-(4-bromophenyl)-N,2-dimethyl-2-phenylpropanamide + C17H18BrNO

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 110 ℃; for 24h; under 34202.3 Torr; Overall yield = 75 percent; regioselective reaction; Autoclave;

DOI:10.1021/jacs.1c03454

upstream raw materials:

formaldehyd

4-bromo-aniline

N-(4-bromophenyl)formamide

Downstream raw materials:

4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide

Refernces

• 1、 Lampland, Nicole L.,Hovey, Megan,Mukherjee, Debabrata,Sadow, Aaron D.. "Magnesium-catalyzed mild reduction of tertiary and secondary amides to amines". . p. 4219 - 4226. Retrieved 2015/11/11.