N-(2,6-Dimethoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2,6-Dimethoxyphenyl)acetamide
• CAS No.: 131157-26-1
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• DSSTox Substance ID: DTXSID30563279
• Nikkaji Number: J2.920.132C
• Wikidata: Q82447681
• Mol file: 131157-26-1.mol

Synonyms:N-(2,6-DIMETHOXYPHENYL)ACETAMIDE;131157-26-1;SCHEMBL7500143;DTXSID30563279;MFCD09909389;AKOS006314611

Chemical Property of N-(2,6-Dimethoxyphenyl)acetamide

Chemical Property:

• Melting Point: 130-132 °C
• Boiling Point: 314.9±22.0 °C(Predicted)
• PKA: 13.87±0.70(Predicted)
• PSA: 51.05000
• Density: 1.144±0.06 g/cm3(Predicted)
• LogP: 2.31170
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 184

Purity/Quality:

N-(2,6-Dimethoxyphenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=CC=C1OC)OC

Technology Process of N-(2,6-Dimethoxyphenyl)acetamide

There total 8 articles about N-(2,6-Dimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,6-dimethoxyaniline (2734-70-5) + acetic anhydride (108-24-7) → N-(2,6-dimethoxyphenyl)acetamide (131157-26-1)

Guidance literature:

for 1.66667h; Ambient temperature;

DOI:10.1248/cpb.38.2118

Reference yield: 94.0%

1-(2,6-dimethoxy-phenyl)-ethanone oxime → N-(2,6-dimethoxyphenyl)acetamide (131157-26-1)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate; at 70 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.090

Reference yield: 93.0%

2,6-dimethoxyaniline (2734-70-5) + acetyl chloride (75-36-5) → N-(2,6-dimethoxyphenyl)acetamide (131157-26-1)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c9cc04550c

upstream raw materials:

2,6-dimethoxyaniline

acetic anhydride

2-nitroresorcinol

1,3-dimethoxy-2-nitrobenzene

Downstream raw materials:

N-(2,6-dihydroxyphenyl)acetamide

C₁₆H₁₄F₃NO₄

C₁₈H₁₆F₃NO₅

C₁₆H₁₆FNO₄