Phenol, 2-chloro-4-ethoxy-

Base Information

• Chemical Name: Phenol, 2-chloro-4-ethoxy-
• CAS No.: 344326-18-7
• Molecular Formula: C8H9ClO2
• Molecular Weight: 172.611
• Hs Code.: 2909500090
• Mol file: 344326-18-7.mol

Synonyms:Phenol, 2-chloro-4-ethoxy-;2-chloro-4-ethoxyphenol

Chemical Property of Phenol, 2-chloro-4-ethoxy-

Chemical Property:

• PSA: 29.46000
• LogP: 2.44430

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-ethoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 2-chloro-4-ethoxy-

There total 7 articles about Phenol, 2-chloro-4-ethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-ethoxy-2-chloro-benzaldehyde (245368-31-4) → 2-chloro-4-ethoxyphenol (344326-18-7)

Guidance literature:

4-ethoxy-2-chloro-benzaldehyde; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;

With water; sodium hydroxide; In methanol; at 20 ℃; for 1h;

Reference yield:

ethanol (64-17-5) + 4,4-dimethoxycyclohexa-2,5-dienone (935-50-2) → 2-chloro-4-methoxyphenol (18113-03-6) + 2-chloro-4-ethoxyphenol (344326-18-7)

Guidance literature:

With N,N'-Dimethylhydrazine dihydrochloride; In acetonitrile; for 1h; regioselective reaction; Reflux;

DOI:10.1039/c4ob00391h

Reference yield:

4-ethoxy-4-methoxycyclohexa-2,5-dien-1-one (73010-52-3) → 2-chloro-4-methoxyphenol (18113-03-6) + 2-chloro-4-ethoxyphenol (344326-18-7)

Guidance literature:

With N,N'-Dimethylhydrazine dihydrochloride; for 0.5h; Overall yield = 24 mg; regioselective reaction; Reflux;

DOI:10.1039/c4ob00391h

upstream raw materials:

4-Ethoxyphenol

4-ethoxybenzaldehyde

ethanol

4,4-dimethoxycyclohexa-2,5-dienone

Downstream raw materials:

2-Aminomethyl-6-chloro-4-ethoxy-phenol; hydrochloride

Refernces

• 1、 Yin, Zhiwei,Zhang, Jinzhu,Wu, Jing,Green, Riana,Li, Sihan,Zheng, Shengping. "Synthesis of o-chlorophenols via an unexpected nucleophilic chlorination of quinone monoketals mediated by N,N′-dimethylhydrazine dihydrochloride". supporting information. p. 2854 - 2858. Retrieved 2014/05/06.