3-(2-METHYLPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE

Base Information

• Chemical Name: 3-(2-METHYLPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE
• CAS No.: 75199-81-4
• Molecular Formula: C₁₀H₉F₃O
• Molecular Weight: 202.176
• Mol file: 75199-81-4.mol

Synonyms:3-(2-METHYLPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE

Chemical Property of 3-(2-METHYLPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE

Chemical Property:

• Vapor Pressure: 0.197mmHg at 25°C
• Boiling Point: 210°C at 760 mmHg
• Flash Point: 94°C
• PSA: 17.07000
• Density: 1.199g/cm³
• LogP: 2.66890

Purity/Quality:

97% ^*data from raw suppliers

3-(2-Methylphenyl)-1,1,1-trifluoro-2-propanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-METHYLPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE

There total 2 articles about 3-(2-METHYLPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(E)-1,1-dimethyl-2-(1,1,1-trifluoro-3-(o-tolyl)propan-2-ylidene)hydrazine → C10H9F3O (75199-81-4)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; tert-butyl methyl ether; at 20 ℃; chemoselective reaction;

DOI:10.1016/j.tetlet.2017.10.022

Reference yield:

ethyl trifluoroacetate, (383-63-1) + 2-methylbenzylmagnesium chloride (29875-05-6) → C10H9F3O (75199-81-4)

Guidance literature:

In diethyl ether; at -78 - 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.5b00087

Reference yield: 35.0%

acetamide (60-35-5) + C10H9F3O (75199-81-4) → (Z)-N-(3,3,3-trifluoro-1-o-tolylprop-1-en-2-yl)acetamide

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Dean-Stark; Reflux;

DOI:10.1021/acs.orglett.5b00087

upstream raw materials:

ethyl trifluoroacetate,

2-methylbenzylmagnesium chloride

Refernces

• 1、 Jiang, Jun,Lu, Wenxin,Lv, Hui,Zhang, Xumu. "Highly efficient synthesis of chiral α-CF3 amines via Rh-catalyzed asymmetric hydrogenation". supporting information. p. 1154 - 1156. Retrieved 2015/03/14.