5-Fluoro-1-MethylbenziMidazole

Base Information

• Chemical Name: 5-Fluoro-1-MethylbenziMidazole
• CAS No.: 1365271-95-9
• Molecular Formula: C8H7FN2
• Molecular Weight: 150.1529832
• Hs Code.: 2933998090
• Mol file: 1365271-95-9.mol

Synonyms:5-Fluoro-1-MethylbenziMidazole

Chemical Property of 5-Fluoro-1-MethylbenziMidazole

Chemical Property:

• PSA: 17.82000
• LogP: 1.71240

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-1-methylbenzimidazole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-1-MethylbenziMidazole

There total 5 articles about 5-Fluoro-1-MethylbenziMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

carbon dioxide (124-38-9,18923-20-1) + 4-fluoro-1,2-phenylenediamine (367-31-7) → 5-fluoro-1-methyl-1H-benzo[d]imidazole (1365271-95-9) + 5-fluoro-1H-benzoimidazole (1977-72-6)

Guidance literature:

With phenylsilane; at 50 ℃; for 3h; under 22502.3 Torr; Pressure; Autoclave;

DOI:10.1039/d0gc02142c

Reference yield: 72.0%

orthoformic acid triethyl ester (122-51-0) + 4-fluoro-N1-methylbenzene-1,2-diamine (401567-10-0) → 5-fluoro-1-methyl-1H-benzo[d]imidazole (1365271-95-9)

Guidance literature:

With ammonium chloride; In ethanol; at 110 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02346

Reference yield:

formic acid (64-18-6) + (4-fluoro-2-nitrophenyl)-(methyl)amine (704-05-2) → 5-fluoro-1-methyl-1H-benzo[d]imidazole (1365271-95-9)

Guidance literature:

With iron; ammonium chloride; In isopropyl alcohol; at 85 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1515/znb-2016-0195

upstream raw materials:

formic acid

(4-fluoro-2-nitrophenyl)-(methyl)amine

1,4-difluoro-2-nitrobenzene

carbon dioxide

Downstream raw materials:

C₁₆H₁₃FN₂

C₁₄H₁₀F₂N₂

C₁₅H₁₃FN₂O

C₁₅H₁₃FN₂

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