Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate

Base Information

• Chemical Name: Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate
• CAS No.: 749928-59-4
• Molecular Formula: C11H11BrO2
• Molecular Weight: 255.111
• Hs Code.: 2916399090
• Mol file: 749928-59-4.mol

Synonyms:Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate;1-(3-Bromo-phenyl)-cyclopropanecarboxylic acid methyl ester;methyl 1-(3-bromophenyl)cyclopropanecarboxylate

Chemical Property of Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate

Chemical Property:

• PSA: 26.30000
• LogP: 2.65370

Purity/Quality:

99% ^*data from raw suppliers

Methyl1-(3-bromophenyl)cyclopropane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate

There total 4 articles about Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 2-(3-bromophenyl)acetatee (150529-73-0) + diphenyl(vinyl)sulfonium trifluoromethanesulfonate → methyl 1-(3-bromophenyl)cyclopropane-1-carboxylate (749928-59-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 21 ℃; for 12h;

DOI:10.1016/j.tetlet.2018.02.080

Reference yield: 64.0%

1-(3-bromophenyl)cyclopropane-1-carboxylic acid (124276-95-5) + methyl iodide (74-88-4) → methyl 1-(3-bromophenyl)cyclopropane-1-carboxylate (749928-59-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 50 ℃;

Reference yield: 56.0%

ethylene dibromide (106-93-4) + methyl 2-(3-bromophenyl)acetatee (150529-73-0) → methyl 1-(3-bromophenyl)cyclopropane-1-carboxylate (749928-59-4)

Guidance literature:

methyl 2-(3-bromophenyl)acetatee; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.25h;

ethylene dibromide; In tetrahydrofuran; at 20 ℃; for 1h;

With lithium hexamethyldisilazane; at 0 - 20 ℃; for 63h;

upstream raw materials:

ethylene dibromide

methyl 2-(3-bromophenyl)acetatee

3-Bromophenylacetic acid

1-(3-bromophenyl)cyclopropane-1-carboxylic acid

Downstream raw materials:

[1-(3-bromophenyl)cyclopropyl]methanol

{[1-(3-bromophenyl)cyclopropyl]methoxy}(triisopropyl)silane

3-(1-{[(triisopropylsilyl)oxy]methyl}cyclopropyl)benzaldehyde

[3-(1-{[(triisopropylsilyl)oxy]methyl}cyclopropyl)phenyl]methanol

Refernces

• 1、 -. "HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE". Paragraph 0510; 0511. . Retrieved 2016/12/16.
• 2、 -. "SUBSTITUTED OXADIAZOLYL PYRIDINONES AND OXADIAZOLYL PYRIDAZINONES AS HIF INHIBITORS". Paragraph 0435; 0436; 0437. . Retrieved 2014/11/13.