(4-chlorophenyl)(4-(trifluoroMethyl)phenyl)Methanone

Base Information

• Chemical Name: (4-chlorophenyl)(4-(trifluoroMethyl)phenyl)Methanone
• CAS No.: 34328-31-9
• Molecular Formula: C14H8ClF3O
• Molecular Weight: 284.665
• Mol file: 34328-31-9.mol

Synonyms:(4-chlorophenyl)(4-(trifluoroMethyl)phenyl)Methanone

Chemical Property of (4-chlorophenyl)(4-(trifluoroMethyl)phenyl)Methanone

Chemical Property:

• PSA: 17.07000
• LogP: 4.58980

Purity/Quality:

99% ^*data from raw suppliers

(4-CHLOROPHENYL)[4-(TRIFLUOROMETHYL)PHENYL]METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chlorophenyl)(4-(trifluoroMethyl)phenyl)Methanone

There total 13 articles about (4-chlorophenyl)(4-(trifluoroMethyl)phenyl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-Chloro-4-iodobenzene (637-87-6) + 4-trifluoromethylphenylboronic acid (128796-39-4) + chromium(0) hexacarbonyl (199620-14-9,13007-92-6) → (4-chloro-phenyl)-(4-trifluoromethyl-phenyl)-methanone (34328-31-9)

Guidance literature:

With sodium t-butanolate; In N,N-dimethyl acetamide; at 80 ℃; for 0.25h;

DOI:10.1007/s10562-019-03087-w

Reference yield: 91.0%

4-trifluoromethylbenzoic acid (455-24-3) + (4-chlorphenyl)magnesium bromide (873-77-8) → (4-chloro-phenyl)-(4-trifluoromethyl-phenyl)-methanone (34328-31-9)

Guidance literature:

4-trifluoromethylbenzoic acid; With tert-butylmagnesium chloride; In tetrahydrofuran; toluene; at 0 ℃; for 0.25h; Inert atmosphere;

(4-chlorphenyl)magnesium bromide; With diisopropylaminomagnesium chloride lithium chloride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 7.25h; Inert atmosphere; Sonication;

DOI:10.1021/acs.orglett.9b02899

Reference yield: 89.0%

sodium (4-trifluoromethylphenyltrihydroxyborate) + 4-chloro-benzoyl chloride (122-01-0) → (4-chloro-phenyl)-(4-trifluoromethyl-phenyl)-methanone (34328-31-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2017.07.001

upstream raw materials:

bromochlorobenzene

4-Trifluoromethylbenzaldehyde

4-trifluoromethylphenylboronic acid

4-chloro-benzoyl chloride

Downstream raw materials:

(4-trifluoromethylphenyl)(4-chlorophenyl)pyrimidin-5-yl methanol

(4-chlorophenyl)(4-trifluoromethylphenyl)pyridin-3-yl methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 34328-31-9 (4-chlorophenyl)(4-(trifluoroMethyl)phenyl)Methanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send