(R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate
CAS No.:152665-79-7
Molecular Formula:C11H17N3O3
Molecular Weight:239.274
Hs Code.:2933990090
Mol file:152665-79-7.mol

Synonyms:(R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

Suppliers and Price of (R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate >95%
500mg
$ 486.00

AK Scientific
(R)-tert-Butyl2-(2-diazoacetyl)pyrrolidine-1-carboxylate
500mg
$ 706.00

Total 2 raw suppliers

Chemical Property of (R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：84.00000
LogP:1.27456

Purity/Quality:

98%min ^*data from raw suppliers

(R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

There total 5 articles about (R)-tert-Butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide

: (R)-2-isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 152665-79-7
(R)-tert-butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

Guidance literature:: N-methyl-N-nitrosotoluene-p-sulfonamide; With potassium hydroxide; In diethyl ether; ethoxyethoxyethanol; water; for 0.5h; Heating;

(R)-2-isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester; In diethyl ether; at 20 ℃; Cooling with ice;
DOI:10.1080/00397910902737155

Reference yield: 56.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 152665-79-7
(R)-tert-butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

Guidance literature:: DOI:10.1002/(SICI)1522-2675(19991006)82:10<1539::AID-HLCA1539>3.0.CO;2-E

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 152665-79-7
(R)-tert-butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

1.2: pH 2 - 3

2.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: potassium hydroxide / diethyl ether; ethoxyethoxyethanol; water / 0.5 h / Heating

3.2: 20 °C / Cooling with ice

With triethylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; ethoxyethoxyethanol; water; 3.2: Arndt-Eistert synthesis;
DOI:10.1080/00397910902737155