tert-butyl 4-(methoxy(methyl)amino)-4-oxobutylcarbamate

Base Information

• Chemical Name: tert-butyl 4-(methoxy(methyl)amino)-4-oxobutylcarbamate
• CAS No.: 227751-84-0
• Molecular Formula: C11H22N2O4
• Molecular Weight: 246.3
• Mol file: 227751-84-0.mol

Synonyms:tert-butyl 4-(methoxy(methyl)amino)-4-oxobutylcarbamate;Tert-Butyl 3-(N-Methoxy-N-Methylcarbamoyl)Propylcarbamate

Chemical Property of tert-butyl 4-(methoxy(methyl)amino)-4-oxobutylcarbamate

Chemical Property:

• Melting Point: 42-43 °C(Solv: hexane (110-54-3))
• PKA: 12?+-.0.46(Predicted)
• PSA: 67.87000
• Density: 1.056±0.06 g/cm3(Predicted)
• LogP: 1.70200

Purity/Quality:

tert-Butyl(4-(methoxy(methyl)amino)-4-oxobutyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(methoxy(methyl)amino)-4-oxobutylcarbamate

There total 3 articles about tert-butyl 4-(methoxy(methyl)amino)-4-oxobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → [3-(N-Methoxy-N'-methyl-carbamoyl)-propyl]-carbamic Acid-tert-butyl Ester (227751-84-0)

Guidance literature:

N-(tert-butoxycarbonyl)-4-aminobutanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; for 1.5h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane;

Reference yield:

N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) + N,0-dimethylhydroxylamine (1117-97-1) → [3-(N-Methoxy-N'-methyl-carbamoyl)-propyl]-carbamic Acid-tert-butyl Ester (227751-84-0)

Guidance literature:

With 4-methyl-morpholine; triethylamine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 20 ℃;

DOI:10.1039/c1ob05187c

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [3-(N-Methoxy-N'-methyl-carbamoyl)-propyl]-carbamic Acid-tert-butyl Ester (227751-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 60 °C

2: 4-methyl-morpholine; triethylamine; isobutyl chloroformate / tetrahydrofuran; N,N-dimethyl-formamide / -15 - 20 °C

With 4-methyl-morpholine; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1039/c1ob05187c

upstream raw materials:

N-(tert-butoxycarbonyl)-4-aminobutanoic acid

N,O-dimethylhydroxylamine*hydrochloride

N,0-dimethylhydroxylamine

di-tert-butyl dicarbonate

Downstream raw materials:

[4-(3,4-dimethoxyphenyl)-4-oxo-butyl]carbamic acid tert-butyl ester

tert-butyl [4-(2-methoxyphenyl)-4-oxobutyl]carbamate

tert-butyl (4-oxo-4-phenyl-butyl)-carbamate

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