tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate

Base Information

• Chemical Name: tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate
• CAS No.: 946000-13-1
• Molecular Formula: C11H15BrN2O2
• Molecular Weight: 287.156
• Hs Code.: 2933399090
• Mol file: 946000-13-1.mol

Synonyms:tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate;(4-BROMO-PYRIDIN-2-YLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property of tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 348.769°C at 760 mmHg
• Flash Point: 164.73°C
• PSA: 42.43000
• Density: 1.391g/cm³
• LogP: 3.21540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(4-bromopyridin-2-yl)(methyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate

There total 7 articles about tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

di-tert-butyl dicarbonate (24424-99-5) + N-(4-bromopyridin-2-yl)-N-methylamine (468718-65-2) → tert-butyl N-(4-bromo-2-pyridyl)-N-(methyl)carbamate (946000-13-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -5 - 20 ℃; for 1.16667h;

Reference yield: 76.0%

(4-bromopyridin-2-yl)-carbamic acid tert-butyl ester (207799-10-8) + methyl iodide (74-88-4) → tert-butyl N-(4-bromo-2-pyridyl)-N-(methyl)carbamate (946000-13-1)

Guidance literature:

(4-bromopyridin-2-yl)-carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

2-methyl-4-nitropyridine N-oxide (5470-66-6) → tert-butyl N-(4-bromo-2-pyridyl)-N-(methyl)carbamate (946000-13-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: iron; acetic acid / 2 h / 20 - 100 °C

2.1: hydrogen bromide; sodium nitrite / water / 16.5 h / -10 - 20 °C

3.1: potassium permanganate / water / 6.5 h / 20 °C / Heating / reflux

5.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

5.2: 16 h / 20 °C

With potassium permanganate; hydrogen bromide; iron; sodium hydride; acetic acid; sodium nitrite; In tetrahydrofuran; water;

upstream raw materials:

(4-bromopyridin-2-yl)-carbamic acid tert-butyl ester

methyl iodide

3-methyl-4-pyridinamine

4-bromo-2-methylpyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 946000-13-1 tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate

Send

Send

Metric Ton KG G Pound L ML

Send

Send