Methyl 5-chloro-3-fluoropyridine-2-carboxylate

Base Information

• Chemical Name: Methyl 5-chloro-3-fluoropyridine-2-carboxylate
• CAS No.: 1200498-40-3
• Molecular Formula: C₇H₅ClFNO₂
• Molecular Weight: 189.574
• Hs Code.: 2933399990
• Mol file: 1200498-40-3.mol

Synonyms:Methyl 5-chloro-3-fluoropyridine-2-carboxylate;Methyl 5-chloro-3-fluoropicolinate;Methyl 5-chloro-3-fluoropicolinate, 5-Chloro-3-fluoro-2-(methoxycarbonyl)pyridine

Chemical Property of Methyl 5-chloro-3-fluoropyridine-2-carboxylate

Chemical Property:

• PSA: 39.19000
• LogP: 1.66070

Purity/Quality:

98% ^*data from raw suppliers

Methyl5-Chloro-3-fluoropyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-chloro-3-fluoropyridine-2-carboxylate

There total 7 articles about Methyl 5-chloro-3-fluoropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%

methanol (67-56-1) + 5-chloro-3-fluoro-2-pyridinecarboxylic acid (207994-08-9) → methyl 5-chloro-3-fluoropicolinate (1200498-40-3)

Guidance literature:

With thionyl chloride; at 20 ℃; Inert atmosphere;

Reference yield:

5-chloro-3-fluoro-2-pyridinecarboxylic acid (207994-08-9) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 5-chloro-3-fluoropicolinate (1200498-40-3)

Guidance literature:

In methanol; diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

methanol (67-56-1) + C6H2ClFNO2(1-)*Li(1+) (1200498-38-9) → methyl 5-chloro-3-fluoropicolinate (1200498-40-3)

Guidance literature:

methanol; C₆H₂ClFNO₂^(1-)*Li⁽¹⁺⁾; With thionyl chloride; for 2h; Reflux;

With sodium hydrogencarbonate;

upstream raw materials:

methanol

C₆H₂ClFNO₂^(1-)*Li⁽¹⁺⁾

5-chloro-3-fluoropyridin-2-ol

2-bromo-5-chloro-3-fluoro-pyridine

Downstream raw materials:

5-cyano-3-fluoropyridine-2-carboxylic acid

(5-chloro-3-fluoropyridin-2-yl)methanol

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