2,6-Dihydroxyterephthalic acid dimethyl ester

Base Information

• Chemical Name: 2,6-Dihydroxyterephthalic acid dimethyl ester
• CAS No.: 35416-55-8
• Molecular Formula: C10H10O6
• Molecular Weight: 226.186
• Mol file: 35416-55-8.mol

Synonyms:2,6-Dihydroxy-1,4-benzenedicarboxylic acid dimethyl ester;2,6-Dihydroxyterephthalic acid dimethyl ester

Chemical Property of 2,6-Dihydroxyterephthalic acid dimethyl ester

Chemical Property:

• PSA: 93.06000
• LogP: 0.67100

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dihydroxyterephthalic acid dimethyl ester

There total 2 articles about 2,6-Dihydroxyterephthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.23%

methanol (67-56-1) + 2,5-dihydroxy-1,4-benzenedicarboxylic acid (69660-39-5) → dimethyl 2,6-dihydroxy-1,4-benzenedicarboxylate (35416-55-8)

Guidance literature:

With thionyl chloride; for 21h; Concentration; Reflux;

Reference yield:

1,4-benzenedicarboxylic acid dimethyl ester (120-61-6) → 2,5-Dihydroxybenzol-1,4-dicarbonsaeure-dimethylester (5870-37-1) + dimethyl 2,3-dihydroxyterephthalate (75956-62-6) + dimethyl hydroxyterephthalate (6342-72-9) + dimethyl 2,6-dihydroxy-1,4-benzenedicarboxylate (35416-55-8)

Guidance literature:

With bubbling air; In water; at 20 ℃; for 12h; Product distribution; Irradiation;

DOI:10.1246/cl.1999.197

Reference yield: 93.0%

dimethyl 2,6-dihydroxy-1,4-benzenedicarboxylate (35416-55-8) + N,N-Dimethylthiocarbamoyl chloride (16420-13-6) → 2,6-bis(dimethylthiocarbamoyloxy)terephthalic acid dimethyl ester

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl acetamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.chempr.2021.05.020

upstream raw materials:

methanol

2,5-dihydroxy-1,4-benzenedicarboxylic acid

1,4-benzenedicarboxylic acid dimethyl ester

Downstream raw materials:

dimethyl 2,6-dimethoxyterephthalate

methyl 3,5-dihydroxy-4-(hydroxymethyl)benzoate

3-Benzyloxy-4-formyl-5-methoxy-benzoic acid methyl ester

3-Benzyloxy-4-dimethoxymethyl-5-methoxy-benzoic acid methyl ester