N2-Trityl OlMesartan Acid

Base Information

Chemical Name:N2-Trityl OlMesartan Acid
CAS No.:752179-89-8
Molecular Formula:C43H40N6O3
Molecular Weight:688.829
Hs Code.:
Mol file:752179-89-8.mol

Synonyms:N2-Trityl OlMesartan Acid

Suppliers and Price of N2-Trityl OlMesartan Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N2-Trityl Olmesartan Acid
5mg
$ 460.00

TRC
N2-TritylOlmesartanAcid
25mg
$ 495.00

TRC
N2-TritylOlmesartanAcid
100mg
$ 1020.00

Medical Isotopes, Inc.
N2-TritylOlmesartanAcid
5 mg
$ 650.00

Total 15 raw suppliers

Chemical Property of N2-Trityl OlMesartan Acid

Chemical Property:

Boiling Point:901.0±75.0 °C(Predicted)
PKA:2.39±0.50(Predicted)
PSA：118.95000
Density:1.22±0.1 g/cm3(Predicted)
LogP:7.97020
Solubility.:DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

N2-Trityl Olmesartan Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N2-Trityl Olmesartan Acid is an intermediate in the synthesis of Olmesartan medoxomil (O550000) related compounds.

Technology Process of N2-Trityl OlMesartan Acid

There total 3 articles about N2-Trityl OlMesartan Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 144689-63-4
olmesartan

: 752179-89-8
1-((2'-(2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

Guidance literature:: olmesartan; With sodium hydroxide; In 1,4-dioxane; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; water; pH=3;

Reference yield:

: dimethyl 2-propyl-1-(4-(2-(trityltetrazol-5-yl)phenyl)phenylmethyl)-imidazole-4,5-dicarboxylate

: 676-58-4
methylmagnesium chloride

: 752179-89-8
1-((2'-(2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

Guidance literature:: dimethyl 2-propyl-1-(4-(2-(trityltetrazol-5-yl)phenyl)phenylmethyl)-imidazole-4,5-dicarboxylate; methylmagnesium chloride; In toluene; at -35 - -30 ℃; for 3h;

With water; acetic acid; In toluene; at -5 - 30 ℃;

Reference yield:

: 58954-23-7
2-propyl-1H-imidazole-4,5-dicarboxylic acid

: 752179-89-8
1-((2'-(2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / Reflux

1.2: 0.25 h

2.1: potassium carbonate / N,N-dimethyl-formamide; acetone / Reflux

3.1: toluene / 3 h / -35 - -30 °C

3.2: -5 - 30 °C

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide; acetone; toluene;