1-(4-BroMo-3-Methylphenyl)cyclopropane-1-carbonitrile

Base Information

• Chemical Name: 1-(4-BroMo-3-Methylphenyl)cyclopropane-1-carbonitrile
• CAS No.: 1314760-71-8
• Molecular Formula: C₁₁H₁₀BrN
• Molecular Weight: 236.111
• Hs Code.: 2926909090
• Mol file: 1314760-71-8.mol

Synonyms:1-(4-BroMo-3-Methylphenyl)cyclopropane-1-carbonitrile

Chemical Property of 1-(4-BroMo-3-Methylphenyl)cyclopropane-1-carbonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 3.31268

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Bromo-3-methylphenyl)cyclopropane-1-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BroMo-3-Methylphenyl)cyclopropane-1-carbonitrile

There total 1 articles about 1-(4-BroMo-3-Methylphenyl)cyclopropane-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.2%

2-(4-bromo-3-methyl-phenyl)acetonitrile (215800-25-2) + ethylene dibromide (106-93-4) → 1-(4-bromo-3-methyl-phenyl)cyclopropanecarbonitrile (1314760-71-8)

Guidance literature:

2-(4-bromo-3-methyl-phenyl)acetonitrile; With sodium hydride; In tetrahydrofuran; paraffin oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

ethylene dibromide; In tetrahydrofuran; paraffin oil; at 20 ℃; for 3h;

Reference yield: 71.0%

1-(4-bromo-3-methyl-phenyl)cyclopropanecarbonitrile (1314760-71-8) + bis(pinacol)diborane (73183-34-3) → 1-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarbonitrile (1818380-84-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

1-(4-bromo-3-methyl-phenyl)cyclopropanecarbonitrile (1314760-71-8) → C17H12F3N5

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2: potassium phosphate; bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; potassium acetate; In 1,4-dioxane; water;

upstream raw materials:

2-(4-bromo-3-methyl-phenyl)acetonitrile

ethylene dibromide

Downstream raw materials:

1-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarbonitrile

Refernces

• 1、 -. "COMPOUNDS AND THEIR METHODS OF USE". Page/Page column 204-205. . Retrieved 2018/06/12.