2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide

Base Information

Chemical Name:2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide
CAS No.:1341200-91-6
Molecular Formula:C₁₂H₁₀Cl₂FN₃O₂S
Molecular Weight:0
Hs Code.:
Mol file:1341200-91-6.mol

Synonyms:2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide

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Technology Process of 2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide

There total 3 articles about 2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1341200-90-5
2-(2,5-dichloropyrimidin-4-yl)-5-fluorobenzene-1-sulfonyl chloride

: 124-40-3
dimethyl amine

: 1341200-91-6
2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ml200198x

Reference yield:

: 1341200-89-2
2,5-dichloro-4-(4-fluorophenyl)pyrimidine

: 1341200-91-6
2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: chlorosulfonic acid / 4 h

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ml200198x

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1341200-91-6
2-(2,5-dichloropyrimidin-4-yl)-5-fluoro-N,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; sodium carbonate; triphenylphosphine / tetrahydrofuran; water / 12 h / Reflux

2: chlorosulfonic acid / 4 h

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With chlorosulfonic acid; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; water; 1: Suzuki coupling;
DOI:10.1021/ml200198x